Clinical Effectiveness and Safety of Multimodal Prehabilitation in Colorectal Cancer Surgery—A Narrative State-of-the-Art Review of Research and Clinical Trials
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Le résumé fourni par la source
Background/Objectives: Colorectal cancer (CRC) remains one of the most common malignancies worldwide. Despite advances in surgical techniques and the implementation of Enhanced Recovery After Surgery (ERAS) protocols, a substantial proportion of patients continue to experience postoperative complications and persistent functional impairment. Multimodal prehabilitation, combining physical exercise, nutritional optimization, and behavioral support, has been proposed as a strategy to enhance functional reserve prior to surgical treatment. The aim of this review was to provide a critical narrative evaluation of current clinical evidence regarding the effectiveness and safety of prehabilitation in patients with CRC. Methods: A targeted literature review was conducted in PubMed, Embase, CINAHL, Scopus, and Web of Science (2015–2025), identifying 23 primary studies, including 18 randomized and 5 non-randomized trials. Results: Most multimodal prehabilitation programs resulted in significant improvements in functional capacity prior to CRC resection. Functional outcomes were most commonly assessed using the six-minute walk test, cardiopulmonary fitness parameters, and measures of muscle strength, with good tolerance and high patient adherence. Several studies also demonstrated reductions in postoperative complication rates, shorter hospital stays, and faster recovery of independence, particularly among older patients, those with frailty, or reduced baseline functional capacity, although these effects were not fully consistent across studies. Conclusions: Available clinical evidence supports multimodal prehabilitation as a safe and feasible strategy that consistently preserves and enhances functional reserve prior to CRC surgery. However, its capacity to modify hard perioperative outcomes (such as complication rates and length of stay) remains inconsistent across current RCTs, showing clear efficacy predominantly in targeted high-risk, frail, or malnourished cohorts.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Clinical Effectiveness and Safety of Multimodal Prehabilitation in Colorectal Cancer Surgery—A Narrative State-of-the-Art Review of Research and Clinical Trials
- Date Crossref
- 27/05/2026
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Wroclaw Medical University pays non établi dans la noticeUniversité ou école supérieure
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Lublin Oncology Center pays non établi dans la noticeStructure de recherche
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Collegium Mazovia Innowacyjna Szkoła Wyższa pays non établi dans la noticeUniversité ou école supérieure
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Cardinal Stefan Wyszynski University in Warsaw pays non établi dans la noticeUniversité ou école supérieure
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Józef Piłsudski University of Physical Education in Warsaw pays non établi dans la noticeUniversité ou école supérieure
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Wrocław University of Science and Technology pays non établi dans la noticeUniversité ou école supérieure
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AGH University of Krakow pays non établi dans la noticeUniversité ou école supérieure
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Łukasiewicz Research Network – PORT Polish Center for Technology Development pays non établi dans la noticeStructure de recherche
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Military Hospital pays non établi dans la noticeÉtablissement de santé
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Department of Gastrointestinal Cancer pays non établi dans la noticeInstitution
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Faculty of Nursing and Midwifery Division of Anesthetic and Surgical Nursing pays non établi dans la noticeUniversité ou école supérieure
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Cardinal Stefan Wyszynski Institute of Cardiology in Warsaw pays non établi dans la noticeStructure de recherche
Wroclaw Medical University, Lublin Oncology Center et Collegium Mazovia Innowacyjna Szkoła Wyższa, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.