Epigenetic ageing during the COVID-19 pandemic: global age acceleration, independent of SARS-CoV-2 infection
Rattachement africain : gb, au, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Abstract Introduction The COVID-19 pandemic had profound effects for both infected and uninfected individuals. We aimed to identify acute and chronic epigenetic alterations from SARS-CoV-2 infection and/or lockdown measures. Methods Both infected and uninfected participants from the TwinsUK cohort (n = 139) provided longitudinal whole-blood samples (Spring 2020, Spring 2021). Cross-sectional and longitudinal DNA methylome [DNAm] changes, including epigenetic ageing clocks, were assessed, and EWAS (Epigenome-Wide Association Studies) were performed. Changes in epigenetic ageing clocks were compared with longitudinal samples from an independent pre-pandemic cohort (n = 35, Nurses’ Health Study II cohort), assessed similarly. Results Irrespective of SARS-CoV-2 infection, all individuals exhibited accelerated ageing from 2020 to 2021 (GrimAge clock age acceleration: p-value = 0.002, β = 0.99). In contrast, epigenetic data from paired samples from a separate pre-pandemic cohort, over a similar time period and assessed similarly, did not exhibit GrimAge acceleration. Epigenetic ageing did not differ between infected and uninfected individuals, or between recent and distant SARS-CoV-2 infection. Lastly, EWAS identified several putative changes in DNAm associated with recent, and distant, SARS-CoV-2 infection. Conclusions Our longitudinal results suggest that the pandemic accelerated epigenetic ageing rates, irrespective of recent or distant SARS-CoV-2 infection.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
Où se fait cette recherche
-
King's College London pays non établi dans la noticeUniversité ou école supérieure
-
Guy's and St Thomas' NHS Foundation Trust pays non établi dans la noticeÉtablissement de santé
-
Bond University pays non établi dans la noticeUniversité ou école supérieure
-
Tufts University pays non établi dans la noticeUniversité ou école supérieure
-
University of Kansas Medical Center pays non établi dans la noticeOrganisme public
-
University College London pays non établi dans la noticeUniversité ou école supérieure
King's College London, Guy's and St Thomas' NHS Foundation Trust et Bond University, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.