Case Report: Cutaneous niche-restricted malignant phenotypes in PTCL-NOS revealed by single-cell sequencing
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Le résumé fourni par la source
Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) presenting with disseminated cutaneous involvement represents an aggressive disease subset with poor response to conventional chemotherapy and dismal prognosis. The tissue-specific molecular mechanisms driving cutaneous aggression remain poorly characterized at single-cell resolution. Here we report a 67-year-old male PTCL-NOS patient with hypertension and coronary artery disease history, presenting with generalized cutaneous nodules and rapid progression despite multi-line chemotherapy. Single-cell RNA sequencing (scRNA-seq) performed on paired skin lesions and peripheral blood at diagnosis revealed striking microenvironmental dichotomy: skin-resident malignant T cells exhibited hyperproliferative phenotypes (high CDC20B, HIST1H3B, MKI67+), activation of NF-κB and IL-17 signaling, and extensive crosstalk with endothelial cells; conversely, blood-derived lymphoma cells displayed immune evasion signatures and metabolic stress markers. Copy number variation analysis confirmed clonal expansion across both compartments with distinct tissue-specific transcriptional programs. Despite CHOP, CHOEP, DA-EPOCH, and AC-CHOP (azacitidine plus chidamide) regimens, the patient experienced primary refractory disease and died 6 months from diagnosis following COVID-19 superinfection. To our knowledge, this is the first case reporting single-cell transcriptomic comparison of skin versus blood compartments in PTCL-NOS, revealing how cutaneous microenvironment sculpts aggressive malignant phenotypes and providing potential targets for compartment-specific therapy.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Case Report: Cutaneous niche-restricted malignant phenotypes in PTCL-NOS revealed by single-cell sequencing
- Date Crossref
- 26/05/2026
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Fujian Medical University pays non établi dans la noticeUniversité ou école supérieure
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First Affiliated Hospital of Fujian Medical University pays non établi dans la noticeÉtablissement de santé
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Shandong Provincial QianFoShan Hospital Shandong Key Laboratory of Digital Diagnosis and Treatment of Thoracic Oncology pays non établi dans la noticeÉtablissement de santé
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Shandong First Medical University Department of Dermatology pays non établi dans la noticeUniversité ou école supérieure
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Shandong University of Traditional Chinese Medicine pays non établi dans la noticeUniversité ou école supérieure
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China Foundation for Youth Entrepreneurship and Employment-Incaier Public Welfare Fund pays non établi dans la noticeEntreprise
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School of Traditional Chinese Medicine pays non établi dans la noticeUniversité ou école supérieure
Fujian Medical University, First Affiliated Hospital of Fujian Medical University et Shandong Key Laboratory of Digital Diagnosis and Treatment of Thoracic Oncology — Shandong Provincial QianFoShan Hospital, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.