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Development of the Italian version of the Neuropathic Pain Questionnaire (NPQ): a reliability and validity study

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To translate, culturally adapt, and assess the psychometric properties of the Italian version of the Neuropathic Pain Questionnaire (NPQ). The Italian version of the NPQ, developed following international guidelines, was administered with other measurement instruments to 110 subjects with neuropathic pain. Structural validity (exploratory factor analysis [EFA]), internal consistency (Cronbach’s alpha), test–retest reliability (intraclass correlation coefficient [ICC]), measurement error (minimal detectable change [MDC]), and construct validity (hypothesis testing) were assessed. EFA reported an one-factor structure (ratio between the first and the second eigenvalue was equal to 3.286, and the variance accounted for by the first factor was equal to 38.9%, with eigenvalues explaining the 38.9% of the variance). Internal consistency was adequate (Cronbach’s alpha = 0.84), and test-retest reliability (assessed in a subsample of 32 subjects) was excellent (ICC = 0.86; 95% CI: 0.74–0.93). The measurement error analysis revealed a MDC equal to 1.08 points (corresponding to 13.2% of the total score range). The construct validity was moderate, as 71.4% (five out of seven) a-priori hypotheses were met. The Italian version of the NPQ is available for clinical and research purposes, as its reliability and validity were met, and it can be used to assess neuropathic pain. The Neuropathic Pain Questionnaire is a reliable and valid outcome measure to assess neuropathic pain.The Neuropathic Pain Questionnaire was translated and cross-culturally adapted into the Italian language.The Neuropathic Pain Questionnaire presented adequate internal consistency, excellent test-retest reliability and moderate construct validity.The Neuropathic Pain Questionnaire can be used in clinical practice by Italian clinicians to assess subjects with neuropathic pain. The Neuropathic Pain Questionnaire is a reliable and valid outcome measure to assess neuropathic pain. The Neuropathic Pain Questionnaire was translated and cross-culturally adapted into the Italian language. The Neuropathic Pain Questionnaire presented adequate internal consistency, excellent test-retest reliability and moderate construct validity. The Neuropathic Pain Questionnaire can be used in clinical practice by Italian clinicians to assess subjects with neuropathic pain.

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