Population-based comparison of post-acute sequelae of COVID-19 and health-related quality of life across pandemic periods: Omicron era versus early pandemic
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Le résumé fourni par la source
Abstract Post-COVID-19 syndrome (PCS) may vary across pandemic phases. We compared the prevalence of post-acute COVID-19 symptom clusters following SARS-CoV-2 infection in the early pandemic and during the Omicron era using a population-based approach. The EPILOC study enrolled individuals aged 18–65 years who tested PCR-positive for SARS-CoV-2 during the early pandemic, between October 2020 and April 2021, in defined geographic regions within Baden-Württemberg. EPILOC-Omicron used an identical design for individuals infected between June and July 2022. Participants completed a standardised questionnaire assessing sociodemographics, lifestyle, symptoms, and health-related quality of life (SF-12). PCS was defined as ≤ 80% recovery of general health or work capacity plus at least one new moderate-to-strong symptom, both compared to before index infection. Generalised linear models adjusted for age, sex, and education were used to estimate relative risks (RRs). We analysed data from 11,710 EPILOC (24% response) and 12,560 EPILOC-Omicron participants (17% response). Participants were similar in age and sex distribution. Vaccination before infection differed markedly (< 3 vs. > 92%). PCS prevalence was 29.6% in EPILOC and 14.5% in EPILOC-Omicron. Predictors of PCS were similar for both. Symptom clusters were consistently less frequent after infection during the Omicron era (e.g., fatigue RR = 0.54; neurocognitive impairment RR = 0.53; chest symptoms RR = 0.47; smell/taste disorder RR = 0.17). Health-related quality of life was similar in PCS cases of both cohorts (mean SF-12 Physical 40.3 vs. 41.0, mean SF-12 Mental 38.9 vs. 40.7). PCS was less common following SARS-CoV-2 infection in the Omicron era compared to the early pandemic period. However, affected individuals continue to experience substantial, comparable impairment in hrQoL across both pandemic periods.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Population-based comparison of post-acute sequelae of COVID-19 and health-related quality of life across pandemic periods: Omicron era versus early pandemic
- Date Crossref
- 19/05/2026
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Universität Ulm pays non établi dans la noticeUniversité ou école supérieure
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University of Freiburg pays non établi dans la noticeUniversité ou école supérieure
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Heidelberg University Department of Infectious Diseases pays non établi dans la noticeUniversité ou école supérieure
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University Children's Hospital Tübingen pays non établi dans la noticeÉtablissement de santé
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University Hospital Heidelberg Department of Internal Medicine IV pays non établi dans la noticeÉtablissement de santé
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University and Rehabilitation Clinics Ulm pays non établi dans la noticeÉtablissement de santé
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University Hospital Ulm pays non établi dans la noticeÉtablissement de santé
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Technische Hochschule Ulm pays non établi dans la noticeUniversité ou école supérieure
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Heidenhain (Germany) pays non établi dans la noticeEntreprise
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Klinik Donaustauf pays non établi dans la noticeÉtablissement de santé
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Zentrum für Psychiatrie Emmendingen pays non établi dans la noticeÉtablissement de santé
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Bernstein Center for Computational Neuroscience Tübingen pays non établi dans la noticeOrganisme public
Universität Ulm, University of Freiburg et Department of Infectious Diseases — Heidelberg University, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.