Neuroprotective polar metabolites with promising antiproliferative potential from the peruvian marine sponge Dysidea Ligneana

Le résumé fourni par la source

Marine sponges are a valuable source of bioactive metabolites. This study investigated the polar fraction of the hydroethanolic extract of the Peruvian marine sponge Dysidea ligneana. Two known polar metabolites, taurine (TAU) and trigonelline (TRG), were isolated and identified by 1D/2D NMR and MS. Their antiproliferative activity was evaluated against HepG-2, MCF-7, HeLa, and WI-38 cells. TRG showed the stronger antiproliferative profile and was further assessed in a diethylnitrosamine-induced hepatocellular carcinoma model, where it attenuated biochemical, oxidative stress, inflammatory, and immunohistochemical alterations in a dose-dependent manner. Neuroprotective activity was evaluated in ceramide-challenged CAD neuronal and MO3.13 oligodendroglial cells, in which TAU showed the more consistent protective effect. Docking analyses suggested plausible interactions of TRG with Keap1 and TAU with caspase-3. These findings support further evaluation of TRG as an antiproliferative candidate and TAU as a neuroprotective candidate.

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