Burden of malaria-HIV coinfection and associated adverse outcomes in Ethiopia: a systematic review and meta-analysis
Rattachement africain : Éthiopie. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: The co-occurrence of malaria and HIV represents a significant health crisis in sub-Saharan Africa, particularly in Ethiopia, where both diseases are prevalent. This synergistic burden aggravates health inequalities, strains healthcare infrastructure, and challenges socioeconomic stability. Investigating the relationship between these co-infections is crucial for enhancing treatment, prevention, diagnosis, and control strategies for malaria in individuals living with HIV. Therefore, this systematic review and meta-analysis aimed to determine the overall burden of malaria-HIV co-infection, as well as the rates of severe anemia, hyperparasitemia, and CD4 + T-cell counts. METHODS: A comprehensive literature search was conducted using several electronic databases, including PubMed, Science Direct, Scopus, and Cochrane, as well as search engines like Google Scholar. A random-effects model was used to calculate pooled burden estimates. Subgroup analysis and funnel plots were utilized to evaluate heterogeneity and publication bias, respectively. RESULT: Of the 429 studies initially reviewed, ten articles met the criteria for inclusion in the final analysis. The pool prevalence estimate of malaria-HIV co-infection was 9% (95% CI 3-15). When grouped by the year of conduct, studies from 2013 to 2025 exhibited the highest malaria burden at 10% (95% CI -4-24), while those conducted from 2002 to 2012 showed the lowest burden at 9% (95% CI 1-16). The overall combined prevalence rates for specific clinical conditions were 31% (95% CI 12-50) for severe anemia, 41% (95% CI -8-90) for hyperparasitemia, and 35% (95% CI 14-56) for low CD4 counts (≤ 200 cells/µL). CONCLUSION: This meta-analysis found that the overall burden of malaria-HIV co-infection in Ethiopia is 9%.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Burden of malaria-HIV coinfection and associated adverse outcomes in Ethiopia: a systematic review and meta-analysis
- Date Crossref
- 19/05/2026
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Gondar Department of Medical Biotechnology University of Gondar, Éthiopie (code pays fourni par la source)Université ou école supérieure
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Ethiopian Public Health Institute Éthiopie (code pays fourni par la source)Structure de recherche
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Dambi Dollo University Department of Biotechnology Éthiopie (pays nommé en fin d’affiliation)Université ou école supérieure
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Ethiopia Public Health Institute Addis Ababa, Éthiopie (pays nommé en fin d’affiliation)Structure de recherche
Department of Medical Biotechnology — University of Gondar (University of Gondar, Éthiopie), Ethiopian Public Health Institute (Éthiopie) et Department of Biotechnology — Dambi Dollo University (Éthiopie), avec 1 autre affiliation. Pays d’affiliation : Éthiopie.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.