Coronary stenosis assessment: AI-based CT quantification, visual analysis of invasive angiography, and quantitative coronary angiography
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Le résumé fourni par la source
OBJECTIVE: To evaluate the diagnostic performance for coronary stenosis of artificial intelligence (AI)-based CT quantification, manual CT quantification, and visual invasive coronary angiography (ICA) assessment against quantitative coronary angiography (QCA). MATERIALS AND METHODS: This retrospective study included patients who underwent both coronary CT angiography (CCTA) and ICA within 1 month. Diameter stenosis (DS) was quantified on CCTA images both automatically by a deep-learning model and manually by radiologists, and was assessed visually on ICA. Diagnostic performance for detecting obstructive stenosis (DS ≥ 50% and ≥ 70%) was assessed against QCA using receiver operating characteristic (ROC) curve analysis on per-patient, per-vessel, and per-segment levels. Agreement with QCA was evaluated using Bland-Altman analysis. RESULTS: A total of 368 patients were included. AI-based CT quantification demonstrated high diagnostic accuracy. For DS ≥ 50%, area under the curves (AUCs) were 0.93 (per-patient), 0.94 (per-vessel), and 0.96 (per-segment). For DS ≥ 70%, AUCs were 0.85, 0.89, and 0.90, respectively. AI-based CT quantification significantly outperformed manual CT and visual ICA assessments at most levels in terms of AUC (all p < 0.05), except vs manual quantification by a senior radiologist at the segment level for ≥ 70% stenosis (p = 0.060). Bland-Altman analysis showed superior agreement between AI-based CT quantification of DS and QCA (mean differences: 1.5% per-patient, -0.7% per-vessel, -1.2% per-segment) compared with manual CT quantification and visual assessment of ICA. CONCLUSIONS: AI-based CT quantification demonstrated high diagnostic performance for obstructive stenosis with good agreement against QCA, outperforming manual CT quantification and visual assessment of ICA in most scenarios, with the exception of segment-level assessment of ≥ 70% DS compared with manual quantification by senior radiologists. CRITICAL RELEVANCE STATEMENT: AI-aided CT quantification outperforms both manual CT quantification and visual ICA analysis in diagnosing obstructive stenosis using QCA as the reference standard, providing an objective tool to reduce diagnostic uncertainty and guide subsequent patient management. KEY POINTS: Manual coronary stenosis quantification is subject to significant inter-observer variability. AI-based CT quantification outperforms both manual CT quantification and visual ICA analysis. Discordance between AI results and the angiographer's visual estimation should prompt a physiological evaluation.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Coronary stenosis assessment: AI-based CT quantification, visual analysis of invasive angiography, and quantitative coronary angiography
- Date Crossref
- 16/05/2026
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Shanghai Jiao Tong University Department of Radiology pays non établi dans la noticeUniversité ou école supérieure
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Shanghai First People's Hospital pays non établi dans la noticeÉtablissement de santé
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Shanghai University of Medicine and Health Sciences Department of Radiology pays non établi dans la noticeUniversité ou école supérieure
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Capital Medical University Department of Radiology pays non établi dans la noticeUniversité ou école supérieure
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Beijing Anzhen Hospital pays non établi dans la noticeÉtablissement de santé
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First Hospital of China Medical University Department of Radiology pays non établi dans la noticeÉtablissement de santé
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China Medical University pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Medical Imaging Technology pays non établi dans la noticeUniversité ou école supérieure
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Ltd Shukun Technology Co. pays non établi dans la noticeEntreprise
Department of Radiology — Shanghai Jiao Tong University, Shanghai First People's Hospital et Department of Radiology — Shanghai University of Medicine and Health Sciences, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.