Monoterpene-indole alkaloid from Rinorea yaundensis and antidiabetic potential of its hydrochloride

Résumé fourni par la source

Abstract Chromatographic resolutions of methanolic extract of the aerial parts of Rinorea yaundensis led to the isolation of a new monoterpene indole alkaloid yaundentine 1 , along with its previously reported hydrochloride 2 and sarpagine 3 , respectively. Moreover, compound 2 was screened to determine its possible antidiabetic properties via oral administration to streptozotocin-induced diabetic rats for 14 days. Their subsequent treatment with compound 2 significantly reduced the blood glucose levels in comparison with control glibenclamide. It could also be validated from the significant reduction in serum lipid profile markers and elevation in HDL-C, also signify the protective effect. The histopathological evaluation further revealed that the reduced number of islet cells were restored near to normal after treatment. This study revealed that compound 2 possesses a potential antidiabetic activity and this effect could be due to the multitarget mode of action, which enables its utility as a complementary drug for diabetes and associated complications.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.