An 8.2μW Fully-Packaged Wireless Implantable SoC for Chemical and Electrical Neural Signal Monitoring

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This work presents the first wireless implantable SoC for multimodal neural signal monitoring. The system integrates fast-scan cyclic voltammetry (FSCV) and organic electrochemical transistor (OECT)-based local field potential (LFP) sensing within a power-constrained, wirelessly powered platform. The SoC comprises a PID-controlled background subtraction loop to enable high-speed DR expansion for FSCV’s fast-varying background currents, a quantization-noise-free arbitrary waveform generator and a reconfigurable potentiostat to support dual-mode sensor excitation without off-chip components, and an energy-efficient rectifier-based dynamic voltage supply (DVS) to mitigate the power bottleneck of the low-noise but power-hungry potentiostat. Fabricated in a 65nm CMOS process, the SoC consumes 8.2μW during 10Hz FSCV scans, while enabling a wide sensor bias voltage range from -0.45V to 1.8V. It achieves at least 3× faster DR expansion loop response than prior techniques while preserving dynamic ranges of 105.3dB for FSCV and 138.8dB for OECT. In vitro validation confirms 208nA/nMol dopamine sensitivity at 400V/s scan rate.

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