MMVverse/MMVmalaria: 1.6.0

Résumé fourni par la source

New functions getExcursionsAboveMIC(): detects each contiguous excursion (time interval) during which concentration stays continuously above the MIC, one row per excursion with its own onset/end time — needed to detect and visualize gaps (troughs dropping back below MIC between doses) for multi-dose regimens, where getTimeAboveMIC()'s summed total can hide a real interruption in coverage. evaluateDoseCriterion_ContinuousTimeAboveMIC(): an alternative to evaluateDoseCriterion_TimeAboveMIC() for predictDose_Generic(), for multi-dose regimens where continuous coverage (no gap) matters, not just the summed total time above MIC. Targets the length of the last uninterrupted excursion above MIC (the one anchored at the profile's global peak and its decline after the final dose) — not the first, which would converge every target duration onto the same "merge every early gap" dose regardless of how long a coverage window was actually requested. Tests tests/testthat/test-keyParameters.R added, covering getExcursionsAboveMIC() and evaluateDoseCriterion_ContinuousTimeAboveMIC(), including an asymmetric-excursion-length case that specifically distinguishes first-vs-last excursion targeting. Closes #11.

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