Cytomegalovirus infection and coronary artery disease in liver transplant recipients: Nationwide study using protocolized cardiac computed tomography

Résumé fourni par la source

OBJECTIVES: Liver transplant recipients have a high burden of coronary artery disease (CAD). Post-transplant cytomegalovirus (CMV) infection is common and is associated with inflammation, possibly promoting atherosclerosis. We investigated if CMV infection is associated with CAD in liver transplant recipients. METHODS: In the Danish Comorbidity in Liver Transplant Recipients (DACOLT) Study (ClinicalTrials.gov: NCT04777032), adult liver transplant recipients underwent research cardiac computed tomography with assessment of CAD and systematic screening for CMV DNAemia. We assessed if prior CMV DNAemia and pre-transplant CMV serostatus were associated with CAD. RESULTS: We included 278 liver transplant recipients, of whom 44% had any calcified plaque (coronary artery calcium score [CACS] ≥1), and 29% had prior CMV DNAemia. The distribution of CACS (P = 0.514) and CAD severity (P = 0.198) did not differ between participants with and without prior CMV DNAemia. Prior CMV DNAemia and positive CMV serostatus were not associated with any calcified plaque (aOR: 0.72 [95% CI: 0.36-1.46] and 1.04 [0.55-1.98], respectively) or any measures of CAD after adjustment for traditional cardiovascular risk factors and time since transplantation. CONCLUSIONS: We found no association between prior CMV infection and CAD in liver transplant recipients, indicating a limited role on postliver transplantation CAD.

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