Blood Pressure Reactivity to Isometric Handgrip Is Augmented in Men Undergoing Androgen Deprivation Therapy for Prostate Cancer

Résumé fourni par la source

Prostate cancer (PCa) is the most common non-skin cancer in men, affecting ~1 in 8 American men. PCa is a hormone sensitive malignancy; accordingly, androgen deprivation therapy (ADT) is a cornerstone of treatment for PCa. However, ADT appears to contribute to the development of hypertension and cardiovascular diseases, although the mechanisms remain unknown at this time. HYPOTHESIS: Our hypothesis is that men undergoing ADT for PCa will have augmented blood pressure (BP) responses to isometric handgrip exercise. METHODS: Men with (N=6; PCa) and without (N=10; Healthy) PCa participated. Men with PCa had been diagnosed within the previous 12 months and were being treated using a gonadotropin releasing hormone agonist for at least eight weeks prior to testing. Men underwent measures of continuous BP monitoring (finger photoplethysmography) and heart rate (electrocardiogram) during 10-minutes of quiet rest. Following rest, isometric handgrip exercise was completed at 30% of maximal voluntary contraction and at a set workload of 100 N for two minutes each. The change in BP was determined during the second minute of each trial. Each handgrip trial was followed immediately by three minutes of postexercise ischemia by inflating a cuff around the upper arm to 250 mmHg. Cross-sectional comparisons between groups were completed using unpaired t-tests. RESULTS: Age (Healthy = 54±6, PCa = 52±4 y; p=0.506), body mass index (Healthy = 25.8±2.7, PCa = 25.0±2.8 kg/m 2 ; p=0.579), were not different between groups, but percent body fat was significantly higher in PCa (Healthy = 27.4±4.5, PCa = 32.2±3.7 %; p=0.046). Testosterone was significantly lower in men undergoing ADT for PCa (24±4 ng/dL) compared to healthy men (491±144 ng/dL; p< 0.001). Resting systolic (Healthy = 125±8, PCa = 124±8 mmHg; p=0.935) and diastolic (Healthy = 80±4, PCa = 82±3 mmHg; p=0.394) BP were not different between groups. During 30% handgrip, workload was significantly lower in men with PCa (Healthy = 116±20, PCa = 76±21N; p=0.002) and systolic BP increases were greater in men on ADT than in healthy men (Healthy = 10.4±4.0, PCa = 17.0±5.8 mmHg; p=0.018). Systolic BP increases were also augmented in men with PCa compared to healthy men during the 100N trial (Healthy = 10.2±2.9, PCa = 17.6±6.7 mmHg; p=0.008). The change in systolic BP from baseline to postexercise ischemia were similar between groups following both 30% handgrip (Healthy = 12.4±7.1, PCa = 10.1±2.6 mmHg; p=0.469) and handgrip at 100N (Healthy = 10.0±6.1, PCa = 9.7±4.3 mmHg; p=0.934). DISCUSSION: These preliminary data suggest that ADT for prostate cancer increases BP reactivity to stress. These findings indicate that autonomic dysfunction may contribute to impaired blood pressure control in prostate cancer patients. FUNDING: K01HL164978 (MCB), R01AG049762 (KLM) This abstract was presented at the American Physiology Summit 2026 and is only available in HTML format. There is no downloadable file or PDF version. The Physiology editorial board was not involved in the peer review process.

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