Landscape and trends in postoperative cognitive dysfunction: A bibliometric and visualized analysis

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BACKGROUND: Postoperative cognitive dysfunction (POCD) is a hot research topic in the field of anesthesia. Despite decades of research, its pathogenesis remains complex, and worldwide research trends are unclear. We intended to analyze the relevant researches on POCD in the past 30 years by using bibliometric methods. METHODS: Based on Web of Science, literature published from January 1, 1993 to December 31, 2022 was retrieved. CiteSpace and VOSviewer were used for descriptive statistical analysis and visualization. RESULTS: A total of 2290 articles are included, and the number reaches peak in 2022 with 277. China is the country with the largest number of publications, but its centrality is relatively low at 0.06, much lower than that of United States (0.67), which ranks first. Capital Medical University is the institution with the highest number of publications, while Duke University is the institution with the highest centrality. The journal that ranks highest in both citations and centrality is ANESTHESIOLOGY. The most cited literature is Monk TG's research published in ANESTHESIOLOGY in 2008, while Wan YJ's research published in ANESTHESIOLOGY in 2007 has the highest centrality. Research hotspots mainly includes 6 aspects: neuroinflammation, cardiac surgery, delirium, general anesthesia, noncardiac surgery, craniopharyngioma and neuron-specific enolase. Burst keywords analysis reveals that recent studies mainly focus on perioperative neurocognitive disorder. CONCLUSION: The global research on POCD is growing rapidly. Future studies need to pay more attention to the etiology and mechanism of POCD, and the research on perioperative neurocognitive disorder will still be the frontier hot spot.

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