Commonalities in frailty and psychopathology predict chronotype across severe mental disorders from a comorbidity perspective

Résumé fourni par la source

Abstract Background Individuals with severe mental illness (SMI) have increased risk of physical comorbidities, linked to worse outcomes such as greater psychopathology, frailty, and neurocognitive impairment. Mechanisms underlying this burden remain unclear. This study examined whether frailty and psychopathology predict evening chronotype, especially in SMI with comorbidities. Methods A longitudinal study assessed 165 participants at two time points over one year: schizophrenia ( n = 30), bipolar disorder ( n = 42), major depressive disorder ( n = 35), and healthy controls ( n = 58). The SMI group ( n = 107) was divided into SMI with comorbidities (SMI-C; n = 47) and without (SMI; n = 60). Measures included psychopathology, frailty, chronotype, neurocognitive and functional performance, and hematological biomarkers. Results Neurocognitive and functional impairments were greater in SMI groups than controls ( F = 10.3–31.4; p < 0.0001; η² p = 0.12–0.34). The SMI-C group showed worse frailty than controls at T1 ( F = 4.3; p < 0.01; η² p = 0.05) and than SMI at T2 ( F = 8.5; p < 0.0001; η² p = 0.12), and elevated MCV/MCH ( F = 3.8–9.4; p < 0.05–0.0001; η² p = 0.04–0.11). Chronotype distribution did not differ. Frailty and psychopathology predicted chronotype in SMI ( p < 0.05–0.01); in controls, frailty and performance did so (p < 0.05). Conclusions Psychopathological and hematological profiles are associated with chronotype and may help identify subgroups for chronobiology-informed interventions. These findings support more personalized treatment approaches.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.