Down-Regulation of Ephrin-B1 in Left Ventricular Non-Compaction

Résumé fourni par la source

Background: Cancer affects patients far beyond the physical burden of disease. Emotional distress, uncertainty, existential suffering, and unmet spiritual needs frequently accompany diagnosis, treatment, survivorship, and end-of-life care. In Ayurveda, Daivavyapashraya Chikitsa refers to spiritually oriented measures such as mantra, observances, ritual, fasting, and faith-based reassurance. Although this framework is well described in classical Ayurvedic thought, its role in modern oncology remains insufficiently defined. Objective: To examine the potential supportive role of Daivavyapashraya Chikitsa in cancer care through an evidence-informed review of Ayurvedic scholarship, spiritual care literature, and integrative oncology research. Methods: A focused narrative review was conducted using PubMed/PubMed Central and authoritative oncology sources. Priority was given to English-language reviews, clinical guidelines, randomized controlled trials, meta-analyses, and major scholarly articles relevant to Ayurveda, spiritual care, meaning-centered interventions, mind-body practices, and mantra/mantram-based approaches in cancer care. Results: Direct oncology-specific evidence on Daivavyapashraya Chikitsa is limited. However, adjacent evidence suggests that spiritually oriented and mind-body interventions may improve anxiety, depression, distress, fatigue, spiritual well-being, and quality of life in patients with cancer. Meta-analyses support modest benefits of psychosocial and spiritual interventions on spiritual well-being, while recent guidelines from the Society for Integrative Oncology and ASCO support selected non-pharmacological interventions for anxiety and depression in cancer settings. Mantra/mantram-based practices appear feasible and potentially beneficial in survivorship settings, although oncology-specific data remain preliminary. Conclusion: Daivavyapashraya Chikitsa should not be presented as a proven anticancer treatment. Rather, it may be understood as a traditional Ayurvedic framework for addressing spiritual and existential suffering within supportive oncology. Its most appropriate contemporary role is as a complementary, patient-centered, culturally sensitive supportive approach, used alongside standard cancer treatment. More rigorous oncology-specific research is needed.

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