Accès ouvert déclaré 2026 article

Incident diabetes within the first two years after SARS-CoV-2 infection: a population-based retrospective cohort study of the Agency for Health Protection of Milan, Italy

Cristina Mazzali, Pietro Magnoni, Maria Grazia Valsecchi, Daria Vigani, Claudio Lucifora, Antonio Giampiero Russo, the PASCNET study group, Federico Franzoni, Gabriele Letta, Laura Antolini, Giuseppe Lapadula, Elena Tassistro, Stefano Denicolai, Marica Grego, Diala Kabbara, Costanza Baldrighi, Alberto Milanese, Rossella Murtas, Andrea Salvatori, Deborah Testa, Sara Tunesi, Adele Zanfino, Simona Dalle Carbonare, Federica Manzoni, Simona Migliazza, Pietro Giovanni Perotti, Linda Guarda, Marco Villa, Silvia Tillati, Giacomo Crotti, Giuseppe Sampietro, Alberto Zucchi, Anita Andreano, Luca Cavalieri d’Oro, Elisabetta Merlo, Magda Rognoni, Piersimone Fontana, Giovanni Maifredi, Ivan Cometti, Anna Clara Fanetti, Maria Letizia Gambino, Monica Lanzoni, Giuseppe Emanuele La Piana, Anna Bussi, Vincenzo Belcastro, Stefano Rusconi, Luigi Magnani, Maurizio Morlotti, Andrea Patroni, Raffaele Bruno, Elisabetta Pagani, Paolo Sacchi, Valentina Zuccaro

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15Institutions déclarées

3Pays d’affiliation déclarés

Rattachement africain : it, jp, mv. Niveau de preuve : code pays fourni par la source.

Le résumé fourni par la source

BACKGROUND: Postacute sequelae of SARS-CoV-2 infection (PASC), including persistent symptoms and acute and chronic diagnoses, have become a major research focus. Diabetes mellitus, beyond its established link to COVID-19 severity, is increasingly recognized as a potential long-term outcome. This study investigated the association between SARS-CoV-2 infection and incident diabetes using population-level health administrative data (HAD) from the Agency for Health Protection of Milan, where the epicenter of the pandemic in Italy took place. METHODS: This retrospective cohort study included adult residents without a history of diabetes who underwent SARS-CoV-2 testing between 1 March and 31 December 2020. Test-positive individuals were matched 1:1 to test-negative individuals based on sex, age, and testing week. The cohort was followed through 31 December 2021. The incidence of diabetes, identified using an HAD-based case-detection algorithm, was compared between the two groups, and in stratified analyses by sex and age, using weighted Cox models adjusted for chronic comorbidities, area-level deprivation, influenza and pneumococcal vaccinations. Weights were calculated via the inverse probability weighting approach. Effect estimates are presented as hazard ratios (HRs). RESULTS: Our final cohort included 248,176 residents (124,026 test-negative, 124,150 test-positive). Over a median follow-up time of 415 days, 739 positive (0.60%) and 657 negative (0.53%) individuals were newly identified with diabetes. The incidence among positive individuals was 572.82 per 100,000 person-years (CI 531.52-614.12), and that among negative individuals was 509.50 per 100,000 person-years (CI 470.54-548.46). The overall HR was 1.13 (CI 1.02-1.25). In stratified analyses, this effect was prominent in women aged 41-60 years (HR 1.31; CI 1.02-1.68). CONCLUSIONS: This study provides population-based evidence supporting an association between SARS-CoV-2 infection and newly detected diabetes. These findings contribute to understanding the long-term health impact of COVID-19 and may inform public health strategies for PASC prevention and management.

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Le contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: Incident diabetes within the first two years after SARS-CoV-2 infection: a population-based retrospective cohort study of the Agency for Health Protection of Milan, Italy
Date Crossref: 11/05/2026
Éditeur: Springer Science and Business Media LLC
Type: journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Où se fait cette recherche

Agenzia Regionale per la Protezione Ambientale del Piemonte pays non établi dans la notice
Organisme public
University of Milano-Bicocca pays non établi dans la notice
Université ou école supérieure
University of Pavia Department of Economics and Management pays non établi dans la notice
Université ou école supérieure
University of the Sacred Heart Department of Economics and Finance pays non établi dans la notice
Université ou école supérieure
Health Protection Agency pays non établi dans la notice
Organisme public
University of Bergamo pays non établi dans la notice
Université ou école supérieure
University of Brescia pays non établi dans la notice
Université ou école supérieure
University of Insubria pays non établi dans la notice
Université ou école supérieure
Azienda Ospedaliera Ospedale Maggiore pays non établi dans la notice
Établissement de santé
Presidio Ospedaliero pays non établi dans la notice
Établissement de santé
Ospedale Maggiore di Lodi pays non établi dans la notice
Établissement de santé
Azienda Ospedaliera Ospedale Civile di Legnano pays non établi dans la notice
Établissement de santé

Agenzia Regionale per la Protezione Ambientale del Piemonte, University of Milano-Bicocca et Department of Economics and Management — University of Pavia, avec 9 autres affiliations.

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

Diabetes and associated disordersCOVID-19 Clinical Research StudiesLong-Term Effects of COVID-19

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