The MabZIP60-MaMYB306-MaWRKY49 Transcriptional Module Balances Resveratrol and Flavonoid Biosynthesis in Mulberry for Enhanced Disease Resistance and Nutritional Quality

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Mulberry fruits and leaves contain resveratrol and flavonoids, which determine their nutritional and functional values, but the molecular mechanism balancing these two metabolites remains unclear. This study identifies a novel transcriptional regulatory module regulating their biosynthesis in mulberry. MaMYB306 functions as a central regulator that directly binds to the MaSTS7 promoter to activate resveratrol biosynthesis while suppressing MaCHS, MaF3H, MaDFR, and MaANS to suppress flavonoid production, redirecting metabolic flux and improving antioxidant capacity and resistance to Botrytis cinerea . Furthermore, MaWRKY49 physically interacts with MaMYB306 to enhance its transcriptional activity, whereas MabZIP60 represses MaMYB306 expression to promote flavonoid accumulation. This MabZIP60-MaMYB306-MaWRKY49 module represents a sophisticated regulatory mechanism that optimizes the balance between the two major phenylpropanoid branches. Our findings provide a novel transcriptional framework for the metabolic engineering of mulberry and other crops to simultaneously enhance health-promoting resveratrol and pathogen resistance, adding value to functional foods and supporting sustainable agriculture.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.