Exosome-Based Therapeutics in Neurological Disorders

Le résumé fourni par la source

Neurological disorders are intricate, progressive, and life-threatening conditions that significantly impact mortality and disability worldwide. Effective treatment options are constricted, primarily due to the presence of the blood–brain barrier (BBB), which thwarts drug delivery to the central nervous system (CNS). Henceforth, overcoming this barrier and developing efficient drug delivery systems for the management of these disorders remains a critical challenge. In this context, exosomes (EXOs)-membranous extracellular vesicles (EVs) derived from diverse biological sources have recently gained significant attention for their theranostic potential in neurological disorders. They play a pivotal role in the efficient transit of various bioactive molecules, including proteins, lipids, and nucleic acids, across the BBB, making them favorable candidates in neurotherapeutic applications. EXOs target several signaling pathways involved in apoptosis, inflammation, and oxidative stress, thereby mitigating the progression of neurological disorders, including Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), stroke, multiple sclerosis (MS), and Parkinson’s disease (PD). In this chapter, a brief overview of the source from which EXOs are derived and their role in various neurological disorders has been emphasized. We have highlighted in detail the role of EXO-based nanoarchitectonics in the management of various neurological disorders. Furthermore, the clinical perspectives of EXO-based therapeutics have been discussed.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.