Risk, Prevalence and Survival Outcomes of Ovarian Cancer in Women With Endometriosis: The Endocancer Systematic Review and Meta-Analysis
Rattachement africain : it. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
OBJECTIVE: Endometriosis is linked to an increased risk of epithelial ovarian cancer (EOC), especially clear cell and endometrioid subtypes. The extent and prognostic significance of this link are still not fully understood. This systematic review and meta-analysis compiles existing evidence on ovarian cancer risk, histotype distribution, and survival outcomes in women with endometriosis. DATA SOURCES: Systematic search up to August 2025. METHODS OF STUDY SELECTION: A systematic search of PubMed and Google Scholar was performed up to August 2025. Studies reporting ovarian cancer risk estimates or survival outcomes in endometriosis-associated ovarian cancer (EAOC) were included. Random-effects models generated pooled odds ratios (OR), hazard ratios (HR), and standardized incidence ratios (SIR). Risk analyses included >500 000 women; survival analyses >10 000. TABULATION, INTEGRATION, AND RESULTS: Sixty-seven studies met inclusion criteria. Endometriosis increased ovarian cancer risk (OR: 1.82, HR: 3.03, SIR: 1.62). EAOC patients were younger, more often premenopausal, and more frequently diagnosed with early-stage (OR: 0.29) and low-grade tumors (OR: 1.71). Clear cell and endometrioid histotypes predominated. Overall survival was significantly better in EAOC (HR: 0.48); recurrence and mortality were lower, while platinum resistance was similar. CONCLUSION: Endometriosis confers an increased relative but still low absolute risk of ovarian cancer. EAOC exhibits distinct clinicopathologic features and improved survival compared with non-EAOC. These findings support personalized counseling and emphasize the need for phenotype-based risk stratification and molecular markers of malignancy transformation.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Risk, Prevalence and Survival Outcomes of Ovarian Cancer in Women With Endometriosis: The Endocancer Systematic Review and Meta-Analysis
- Date Crossref
- 01/09/2026
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Santa Maria Nuova Hospital pays non établi dans la noticeÉtablissement de santé
-
University of Udine in Department of Medicine (DMED) pays non établi dans la noticeUniversité ou école supérieure
-
Ospedale Santa Maria della Misericordia di Udine pays non établi dans la noticeÉtablissement de santé
-
Azienda sanitaria universitaria Friuli Centrale pays non établi dans la noticeÉtablissement de santé
-
Azienda Usl Toscana Centro pays non établi dans la noticeÉtablissement de santé
-
IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola pays non établi dans la noticeÉtablissement de santé
-
University of Siena Department of Molecular and Developmental Medicine pays non établi dans la noticeUniversité ou école supérieure
-
Santa Maria Hospital (Piacenti) Gynecology and Obstetric Department pays non établi dans la noticeÉtablissement de santé
-
"S. Maria Della Misericordia" University Hospital (Restaino Clinic of Obstetrics and Gynecology pays non établi dans la noticeUniversité ou école supérieure
-
Santa Maria Annunziata Hospital (Perelli Gynecology and Obstetric Department pays non établi dans la noticeÉtablissement de santé
-
IRCCS Azienda Ospedaliero-Universitaria di Bologna Policlinico di Sant'Orsola pays non établi dans la noticeÉtablissement de santé
Santa Maria Nuova Hospital, in Department of Medicine (DMED) — University of Udine et Ospedale Santa Maria della Misericordia di Udine, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.