Intravascular lithotripsy for calcified coronary lesions: contemporary trends and long-term outcomes in acute myocardial infarction patients — insights from the CLEAR registry
Rattachement africain : pl, gb, nl. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Intravascular lithotripsy (IVL) utilizes high-energy sonic waves to create controlled fractures in calcified plaques, facilitating vessel preparation and improving stent apposition. METHODS: The study was designed to evaluate the safety and efficacy of IVL in a patient population that included individuals with acute myocardial infarction (MI). A total of 201 consecutive patients who underwent percutaneous coronary intervention (PCI) using IVL [Shockwave C2 or C2+ (Shockwave Medical Inc, Santa Clara, CA, US)] from April 2020 onward were included in this single-center registry. The study population comprised 76 patients with acute MI (Group 1) and 125 patients with non-MI (Group 2). RESULTS: Left ventricular ejection fraction was lower (46.0% ± 13.1% vs. 50.9% ± 10.5%; p = 0.022), while SYNTAX Score was significantly higher (20.0 ± 11.3 vs. 16.5 ± 10.2; p = 0.059) in Group 1 than in Group 2 (46.0% ± 13.1% vs. 50.9% ± 10.5%; p = 0.022). The overall IVL success rate and procedure success rate were very high (97.5% and 99.5%, respectively). A mean increase in lumen area was observed in Group 1 and Group 2: 5.9 ± 3.7 mm2 vs. 4.5 ± 2.2 mm2 and 237% vs. 239%, respectively. In the long-term follow-up there was no difference in all-cause mortality between Group 1 and Group 2 (9.0% vs. 8.1%; p = 0.997), cardiac death (p = 0.340), repeat MI (p = 0.986) and major adverse cardiovascular events [MACE; cardiac death, myocardial infarction, stroke] (16.8% vs. 9.8%; p = 0.501). Prior chronic kidney disease (CKD), post rota-atherectomy debulking, prior coronary artery bypass graft (CABG) and longer lesions were independent predictors of long-term all-cause mortality. CONCLUSIONS: Intravascular lithotripsy is an effective treatment for the modification of calcified atherosclerotic lesions, with a high success rate and few periprocedural complications. The long-term outcomes achieved in this complex population are satisfactory.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Intravascular lithotripsy for calcified coronary lesions: contemporary trends and long-term outcomes in acute myocardial infarction patients — insights from the CLEAR registry
- Date Crossref
- 05/02/2026
- Éditeur
- VM Media Group sp. z o.o
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Poznan University of Medical Sciences Department of Cardiology pays non établi dans la noticeUniversité ou école supérieure
-
Surrey and Sussex Healthcare NHS Trust pays non établi dans la noticeÉtablissement de santé
-
Maasstad Ziekenhuis pays non établi dans la noticeÉtablissement de santé
-
Institute of Cardiology pays non établi dans la noticeStructure de recherche
-
Medical University of Silesia pays non établi dans la noticeUniversité ou école supérieure
-
Department of Cardiology pays non établi dans la noticeInstitution
-
Maasstad Hospital Department of Cardiology pays non établi dans la noticeÉtablissement de santé
-
National Institute of Car diology Department of Inter ventional Cardiology and Angiology pays non établi dans la noticeStructure de recherche
-
Faculty of Medical Sciences in Zabrze pays non établi dans la noticeUniversité ou école supérieure
Department of Cardiology — Poznan University of Medical Sciences, Surrey and Sussex Healthcare NHS Trust et Maasstad Ziekenhuis, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.