Prostate Cancer in a Sub-Saharan Tertiary Level Setting: Profile of Contemporary Gleason Grading Over 13 years
Rattachement africain : sa, Rwanda, mt, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background Prostate cancer (PCa) remains one of the leading causes of cancer morbidity and mortality among men worldwide, yet data from Sub-Saharan Africa are scarce. Although African American men are known to present with more aggressive disease than White men, little is known about the pathological profile of PCa among Black African men. The Gleason grading system, updated by the International Society of Urological Pathology (ISUP) in 2014, remains integral in assessing tumor aggressiveness and prognosis. This study describes the histopathological and clinical characteristics of PCa cases diagnosed at King Faisal Hospital, Rwanda (KFH) over 13 years. Methods A retrospective review of all histologically confirmed PCa cases diagnosed at KFH between 2010 and 2022 was conducted. Tumor aggressiveness was classified according to the ISUP 2014 grading system. To ensure consistency, all slides reported between 2010 and 2014 were re-examined and reclassified using the ISUP 2014 criteria. Demographic, clinical, and treatment-related information was retrieved from patient medical records. Data were summarized using descriptive statistics. Results A total of 245 patients were identified, and 82.1% had a histological diagnosis. More than half of the patients (53.9%) were 70 years or younger at diagnosis, with a mean age at diagnosis of 68 years. Aggressive disease was observed in 55.5% of cases (Grade Group [GG] 4: 31.4%; GG 5: 24.1%). Despite some missing data, 38% presented with high-risk or metastatic PCa, typically characterized by prostate-specific antigen (PSA) levels >20 ng/mL or cancer-related symptoms. Androgen deprivation therapy (ADT) was the most common treatment modality. Conclusion Over half of the Rwandan men with PCa at KFH present with aggressive disease, often at a younger age. These findings underscore the urgent need for national screening programs, public awareness efforts, and comprehensive cancer registries to improve early detection and management in Rwanda and the broader region.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Prostate Cancer in a Sub-Saharan Tertiary Level Setting: Profile of Contemporary Gleason Grading Over 13 years
- Date Crossref
- 01/01/2026
- Éditeur
- African Journals Online (AJOL)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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King Faisal Specialist Hospital & Research Centre pays non établi dans la noticeÉtablissement de santé
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King Faisal Hospital Rwanda Department of Surgery Rwanda (code pays fourni par la source)Établissement de santé
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University Teaching Hospital of Butare Department of Surgery University Teaching Hospital of Butare, Rwanda (code pays fourni par la source)Établissement de santé
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Primary HealthCare pays non établi dans la noticeÉtablissement de santé
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Dartmouth College N/A pays non établi dans la noticeUniversité ou école supérieure
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University of Minnesota Department of Surgery pays non établi dans la noticeUniversité ou école supérieure
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University of Minnesota System pays non établi dans la noticeUniversité ou école supérieure
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University of Rwanda Department of Primary Healthcare Rwanda (pays nommé en fin d’affiliation)Université ou école supérieure
King Faisal Specialist Hospital & Research Centre, Department of Surgery — King Faisal Hospital Rwanda (Rwanda) et Department of Surgery — University Teaching Hospital of Butare (University Teaching Hospital of Butare, Rwanda), avec 5 autres affiliations. Pays d’affiliation : Rwanda.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.