Evaluation of Therapeutic Efficacy of Antioxidants in Psoriatic Cases: A Prospective Study

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Background: Psoriasis is a chronic inflammatory skin disorder characterized by excessive proliferation of keratinocytes and immune-mediated inflammation. Oxidative stress has been implicated as an important factor in the pathogenesis of psoriasis. Antioxidants may help reduce oxidative damage and improve clinical outcomes in psoriatic patients. Objective: To evaluate the therapeutic efficacy of antioxidant supplementation in patients with psoriasis and to determine its effect on clinical severity and oxidative stress markers. Materials and Methods: A prospective observational study was conducted at Patna Medical College, Patna, Bihar, India, over a period of eight months from March 2025 to November 2025. Eighty patients diagnosed with psoriasis were included in the study. Clinical severity was assessed using the Psoriasis Area and Severity Index (PASI). Serum antioxidant levels including superoxide dismutase (SOD), catalase, and malondialdehyde (MDA) were measured before and after antioxidant therapy. Statistical analysis was performed using SPSS software version 26. Paired t-test and correlation analysis were applied to determine statistical significance. Results: Following antioxidant therapy, significant improvement was observed in PASI scores and oxidative stress markers. Mean PASI score reduced from 14.6 ± 3.8 to 8.2 ± 2.9 (p < 0.001). Serum SOD and catalase levels increased significantly, while MDA levels decreased. Clinical improvement was observed in 72.5% of patients. Conclusion: Antioxidant supplementation demonstrated beneficial effects in reducing oxidative stress and improving clinical symptoms in psoriasis. The findings suggest that antioxidants may serve as useful adjunctive therapy in psoriasis management.