Accès ouvert déclaré2026article
High Nasopharyngeal SARS-CoV-2 Load and Delayed Clearance in Hospitalized Patients With Blood Autoantibodies Neutralizing Type I Interferons
Astrid Marchal, Thibault Kerdiles, Aglaé Perrin, Adrian Gervais, Paul Bastard, Lucy Bizien, Guillaume Lingas, Clément Massonnaud, Maude Bouscambert-Duchamp, Alexandre Gaymard, Nathan Peiffer-Smadja, France Mentré, Jérémie Guedj, Laurent Abel, Jean-Laurent Casanova, Anne Puel, Maya Hites, Florence Ader, Julie Bertrand, Aurélie Cobat, the DisCoVeRy Study Group, Sandrine Couffin-Cadièrgues, C Delmas, H Esperou, Bernd Lamprecht, M Joannidis, Alexander Egle, Richard Greil, Antoine Altdorfer, Vincent Fraipont, Leila Belkhir, Gil Verschelden, Violaine Tolsma, David Bougon, Agathe Delbove, Marie Gousseff, Nadia Saïdani, Guilhem Wattecamps, Félix Djossou, Loïc Epelboin, Jean‐Philippe Lanoix, Pierre-Alexandre Roger, Claire Andrejak, Yoann Zerbib, K Bouiller, Catherine Chirouze, Jean-Christophe Navellou, Alexandre Boyer, Charles Cazanave, Alexandre Duvignaud, Didier Gruson, Denis Malvy, Henry Lessire, Martin Martinot, Pascal Andreu, Mathieu Blot, Lionel Piroth, Jean Pierre QUENOT, Olivier Épaulard, Nicolas Terzi, Karine Faure, Emmanuel Faure, J Poissy, Saad Nseir, Laurent Argaud, Tristan Ferry, Thomas Perpoint, Vincent Piriou, Jean-Christophe Richard, Julien Textoris, F Valour, Florent Wallet, André Cabié, Jean-Marie Turmel, Cyrille Chabartier, Rostane Gaci, Céline Robert, A Makinson, V Le Moing, Kada Klouche, O. Hinschberger, Joy Mootien, Sébastien Gibot, F Goehringer, Antoine Kimmoun, B Lefèvre, David Boutoille, Emmanuel Canet, Benjamin Gaborit, Paul Le Turnier, François Raffi, J Reignier, Johan Courjon, Jean Dellamonica, Sylvie Leroy, Charles‐Hugo Marquette, P Loubet, C. Roger, Albert Sotto, C Bruel, B Pilmis, Guillaume Géri, Elisabeth Rouveix-Nordon, Olivier Bouchaud, Figueiredo Sde A, Stéphane Jaureguiberry, Xavier Monnet, Lila Bouadma, F Lescure, Nathan Peiffer-Smadja, J F Timsit, Y Yazdanpanah, Solen Kernéis, Marie Lachâtre, Odile Launay, Jean-Paul Mira, J F Mayaux, Valérie Pourcher, Jérôme Aboab, Flora Crockett, Naomi Sayre, Clément Dubost, C. Ficko, David Lebeaux, S Gallien, Armand Mekontso-Dessap, Jérôme Le Pavec, Francois Stefan, Hafid Ait‐Oufella, Karine Lacombe, Jean-Michel Molina, Murielle Fartoukh, Gilles Pialoux, F Bani-Sadr, Bruno Mourvillier, François Benezit, Fabrice Laine, Bruno Laviolle, Yves Le Tulzo, M Revest, E Botelho-Nevers, A Gagneux-Brunon, Guillaume Thiery, Raphaël Clere-Jehl, François Danion, Y Hansmann, Ferhat Meziani, Walid Oulehri, Yvon Ruch, Charles Tacquard, Fanny Bounes-Vardon, Guillaume Martin-Blondel, Marlène Murris-Espin, Béatrice Riu-Poulenc, Vanessa Jean-Michel, E Senneville, Louis Bernard, D Garot, Jean Reuter, T Staub, Marc J. Berna, Sandra Bráz, João Miguel Ribeiro, José-Artur Paiva, Roncon-Albuquerque Júnior R, Maude Bouscambert-Duchamp, Benjamin Leveau, B Lina, Minh-Patrick Lê, G Peytavin, Sarah Tubiana, Aline Dechanet, Juliette Saillard, Marina Dumousseaux, Assia Ferrane, Claire Fougerou‐Leurent, Marion Noret, Alpha Diallo, Noémie Mercier, Vida Terzić, Drifa Belhadi, Charles Burdet, Jérémie Guedj, Priyanka Velou, Dominique Costagliola
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Résumé fourni par la source
Autoantibodies neutralizing type I interferon (AAN-I-IFNs) underlie life-threatening COVID-19. In hospitalized COVID-19 patients of the DisCoVeRy trial (NCT-04315948), AAN-I-IFNs were associated with higher nasopharyngeal viral load at inclusion (P = 1.4 × 10-3) and delayed viral clearance (P = .013). Blood AAN-I-IFNs, high viral load and delayed clearance were also independent risk factors for critical COVID-19.
Sujets associés
COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 ResearchLong-Term Effects of COVID-19