Procalcitonin Levels in ICU Patients with SARS-CoV-2-Associated Viral Sepsis
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Le résumé fourni par la source
Background: Sepsis has heterogeneous etiologies. Although bacteria are the most common causative agents, viral and yeast forms of sepsis also occur. Procalcitonin (PCT) is widely used to monitor severe bacterial infections and may support the differential diagnosis of infection etiology. Methods: We evaluated the diagnostic value of PCT in viral sepsis using PCT levels at ICU admission and PCT kinetics during ICU treatment. Results: During the COVID-19 pandemic, 191 adult ICU patients with sepsis and a positive SARS-CoV-2 PCR test at hospital admission were included and classified into two groups according to the presence or absence of bacterial or yeast co-infection. PCT showed a distinct diagnostic pattern influenced by the presence of co-infection. PCT remained low in isolated viral sepsis, whereas elevated concentrations were associated with superimposed bacterial or yeast co-infection and worse clinical outcomes. Overall mortality was significantly lower in patients with isolated viral sepsis compared to those with co-infection (50 vs. 69%, p = 0.009). Conclusions: In viral sepsis, persistently low PCT concentrations argue against bacterial co-infection, whereas elevated or rising values should prompt increased diagnostic evaluation. Although PCT provides clinically relevant diagnostic information, it must be interpreted cautiously and in conjunction with clinical assessment and microbiological data. PCT should serve as an adjunctive, not a standalone, marker of infection etiology in sepsis.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Procalcitonin Levels in ICU Patients with SARS-CoV-2-Associated Viral Sepsis
- Date Crossref
- 27/04/2026
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Wroclaw Medical University Clinical Department of Anesthesiology and Intensive Therapy pays non établi dans la noticeUniversité ou école supérieure
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Central Clinical Hospital pays non établi dans la noticeÉtablissement de santé
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Military Hospital pays non établi dans la noticeÉtablissement de santé
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University Clinical Hospital Clinical Department of Anesthesiology and Intensive Therapy pays non établi dans la noticeUniversité ou école supérieure
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Department of Cardiology pays non établi dans la noticeInstitution
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Faculty of Medicine Clinical Department of Paediatric Nephrology pays non établi dans la noticeUniversité ou école supérieure
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University Centre of General and Oncological Surgery Department of General Surgery pays non établi dans la noticeUniversité ou école supérieure
Clinical Department of Anesthesiology and Intensive Therapy — Wroclaw Medical University, Central Clinical Hospital et Military Hospital, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.