Accès ouvert déclaré 2026 other

Pathways to resilience: relationships between cognitive reserve, psychological debt, and Alzheimer’s disease biomarkers

Hanna Boscheck, Maxie Luft, René Mauer, Selin Senguel, Ylenia D’elia, Peter Dechent, Klaus Fliessbach, Wenzel Glanz, Stefan Hetzer, Daniel Janowitz, Ingo Kilimann, Luca Kleineidam, Marie Kronmüller, Falk Lüsebrink, Lukas Preis, Boris Rauchmann, Ayda Rostamzadeh, Björn Hendrik Schott, Sebastian Sodenkamp, Eike Spruth, Sophia Stoecklein, Renat Yakupov, Gabriel Ziegler, Frederic Brosseron, Katharina Buerger, Julian Hellmann-Regen, Christoph Laske, Robert Perneczky, Oliver Peters, Josef Priller, Alfredo Ramirez, Anja Schneider, A Spottke, Stefan Teipel, Jens Wiltfang, Frank Jessen, Emrah Düzel, Sandra Röske, Michael Wagner, Franka Glöckner, Natalie L. Marchant, Olga Klimecki, Miranka Wirth

0Citations signalées, ce qui n’est pas une note de qualité

22Institutions déclarées

5Pays d’affiliation déclarés

Rattachement africain : de, us, gb, pt, at. Niveau de preuve : code pays fourni par la source.

Le résumé fourni par la source

Abstract Background Potentially modifiable lifestyle and psychological factors may influence Alzheimer’s disease (AD)-related brain pathology and cognitive function, thereby influencing cognitive resilience in late life. Objective This cross-sectional study investigated associations and pathways between lifestyle and psychological factors related to cognitive reserve and psychological debt, AD-related biomarkers, and cognitive function, as well as potential differences in these associations between AD risk groups. Methods In total, 298 non-demented older adults (mean age = 69.5 years, 44% women) of the DELCODE study were included. Structural equation modeling was used to assess the associations between the constructs of cognitive reserve (education, occupational complexity, leisure activity participation) and psychological debt (depression and anxiety symptoms, neuroticism, sleep quality), manifest AD-related biomarkers (cerebrospinal fluid [CSF] amyloid-beta [Aβ] 42, splenial white matter hyperintensities [WMH], hippocampal volume), and latent cognitive function of increased AD risk (Preclinical Alzheimer’s Cognitive Composite [PACC]). In the structural equation model, biomarkers were transformed such that higher values indicated greater AD-related brain pathology and age was included as a covariate. Multigroup analyses assessed moderations by established AD risk modifiers, namely sex and apolipoprotein ε4 (APOE ε4) genotype. Results In the total sample, higher cognitive reserve was associated with better cognitive function (p = .005), independent of AD-related biomarkers. Higher cognitive reserve was associated with lower psychological debt (p = .035); however, neither construct showed a significant association with the AD-related biomarkers (p ≥ .177). AD-related biomarkers of CSF Aβ42 (p = .021), splenial WMH (p = .044), and hippocampal neurodegeneration (p = .007) were each independently associated with lower cognitive function. Most associations were comparable between AD risk groups stratified by sex and APOE ε4 genotype. The relationships between cognitive reserve and psychological debt, and between CSF Aβ42 and splenial WMH were stronger in APOE ε4 non-carriers than in carriers (all p ≤ .020). Conclusions Cognitive reserve emerges as a key resilience pathway, supporting late-life cognition independently of AD-related pathology, with largely consistent effects across AD risk groups. The role of psychological debt warrants longitudinal investigation, particularly in vulnerable older populations. Trial registration German Clinical Trials Register: DRKS00007966, Registered: 4 May 2015.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.

Le contrôle bibliographique ouvert

La source scientifique ouverte est momentanément indisponible.

Où se fait cette recherche

German Center for Neurodegenerative Diseases pays non établi dans la notice
Structure de recherche
Technische Universität Dresden pays non établi dans la notice
Université ou école supérieure
University of Southern California pays non établi dans la notice
Université ou école supérieure
California Southern University pays non établi dans la notice
Université ou école supérieure
Universitätsmedizin Göttingen pays non établi dans la notice
Établissement de santé
University Hospital Bonn pays non établi dans la notice
Établissement de santé
Charité - Universitätsmedizin Berlin pays non établi dans la notice
Établissement de santé
University of Rostock pays non établi dans la notice
Université ou école supérieure
Otto-von-Guericke-Universität Magdeburg pays non établi dans la notice
Université ou école supérieure
LMU Klinikum pays non établi dans la notice
Établissement de santé
University of Sheffield pays non établi dans la notice
Université ou école supérieure
University of Cologne pays non établi dans la notice
Université ou école supérieure

German Center for Neurodegenerative Diseases, Technische Universität Dresden et University of Southern California, avec 9 autres affiliations.

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Lire en accès ouvert Consulter la publication primaire Ouvrir le DOI