[Research progress on the Co-Presentation of CD8+ T cell antigen epitopes by HLA-A*02 and HLA-E in infectious diseases].

Le résumé fourni par la source

T cell-mediated anti-pathogen immune responses. This review systematically compares the structural and functional bases of antigen presentation mechanisms, particularly focusing on their shared capacity to present pathogen-derived epitopes during infectious diseases for HLA-A*02 and HLA-E. We further discussed the roles of their co-presentation phenomenon in host defense and immune homeostasis maintenance. The design of novel peptide vaccines based on the co-presentation of antigenic epitopes by HLA-A*02 and HLA-E may overcome limitations posed by HLA polymorphism, offering a theoretical basis and novel strategies for achieving broader and longer-lasting immune protection.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.