Modeling the Effect of L-Arginine on the Electrochemical Reduction of Oxygen in Physiological Solution

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Abstract Arginine (L-arginine) is a conditionally essential amino acid that plays a crucial role in the body’s biochemical and physiological processes. It lowers malondialdehyde levels, a marker of lipid peroxidation, and promotes the activation of superoxide dismutase, an enzyme that protects cell membranes, DNA, and proteins from oxidative damage. Its antioxidant effects are expressed both through direct neutralization of free radicals and indirectly by enhancing the activity of endogenous enzymes. Therefore, modeling the effect of L-arginine on the electrochemical reduction of oxygen in physiological solution by experimentally evaluating its ability to inhibit free radical processes is highly relevant. Oxygen reduction processes were studied using voltammetry with an IPC-Pro M potentiostat combined with the Module EM-04 electrochemical sensor. Device operation and primary data processing were controlled using the IPC2000 software on a personal computer. The results showed that during the electroreduction of oxygen, a single well-defined peak appears on the voltammograms, which shifts upon the introduction of L-arginine into the solution, independent of the electrode type. This confirms its antioxidant activity and suggests its potential as both a free radical inhibitor and an effective regulator of oxidative stress in the human body.

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