Elevated serum brain injury markers are associated with disease activity, pro-inflammatory cytokine levels and cognitive dysfunction in adolescents with childhood-onset SLE
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Le résumé fourni par la source
OBJECTIVE: This study examined serum brain injury markers and their associations with disease features, cytokines associated with microglial activation in lupus and cognitive dysfunction (CD) in adolescents with childhood-onset SLE (cSLE). METHODS: We used cross-sectional data from cSLE patients (aged 12-17 years) and age-matched, sex-matched healthy controls. Serum levels of brain injury markers (serum neurofilament light, glial fibrillar acidic protein (GFAP), Tau), interferon (IFN)-α, IFN-γ and interleukin-6 (IL-6) were quantified using Simoa assays. cSLE features included disease activity (Systemic Lupus Erythematosus Disease Activity Index 2000), damage (Systemic Lupus International Collaborating Clinics damage index) and glucocorticoid (GC) exposure. A neurocognitive battery assessed executive function, attention and working memory, and CD was determined using standardised scores. We compared brain injury marker levels between cSLE and controls, and those with and without CD using Wilcoxon rank-sum tests. We calculated correlations between injury markers, disease features and cytokines and examined differences in disease features between those with and without high-level brain injury markers (>90th percentile) (using Bonferroni correction). RESULTS: Participants included 56 cSLE patients (median disease duration=10.6 months (IQR 2.0-14.1), one with neuropsychiatric lupus) and 43 controls. Levels were higher in cSLE versus controls for GFAP (z=-3.97, p<0.001), Tau (z=-2.10, p=0.035), IFN-α (z=-4.80, p<0.001), IFN-γ (z=-2.42, p=0.015) and IL-6 (-3.09, p=0.002). Severe CD (≥2 SD from standardised mean) was present in 31% cSLE versus 9% controls (chi2=6.69, p=0.01), associated with higher Tau levels for cSLE (z=-3.94, p<0.001). High-level brain injury markers were observed in 13 (23%) cSLE patients associated with higher SLEDAI-2K, IL-6 levels and current GC dose. CONCLUSION: Brain injury marker levels were high and associated with disease activity and CD in this cSLE adolescent cohort, suggesting a link between systemic inflammation and clinically under-detected neuronal/glial injury. Larger, longitudinal studies should explore the potential clinical utility of brain injury markers for clinical assessment of brain involvement in cSLE.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Elevated serum brain injury markers are associated with disease activity, pro-inflammatory cytokine levels and cognitive dysfunction in adolescents with childhood-onset SLE
- Date Crossref
- 01/01/2026
- Éditeur
- BMJ
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Dr. Georges-L.-Dumont University Hospital Centre pays non établi dans la noticeÉtablissement de santé
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Sickkids Research Institute Neurosciences and Mental Health Program pays non établi dans la noticeStructure de recherche
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Children's Hospital of Eastern Ontario Division of Rheumatology pays non établi dans la noticeÉtablissement de santé
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Hospital for Sick Children Department of Psychology pays non établi dans la noticeÉtablissement de santé
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University of Toronto Department of Paediatrics pays non établi dans la noticeUniversité ou école supérieure
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University Health Network Schroeder Arthritis Institute pays non établi dans la noticeÉtablissement de santé
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Krembil Research Institute pays non établi dans la noticeStructure de recherche
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Dr. Georges‑L.‑Dumont University Hospital Centre Pediatrics & Rheumatology pays non établi dans la noticeUniversité ou école supérieure
Dr. Georges-L.-Dumont University Hospital Centre, Neurosciences and Mental Health Program — Sickkids Research Institute et Division of Rheumatology — Children's Hospital of Eastern Ontario, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.