Effect of Hypericum perforatum on Early Wound Healing after Tooth Extraction: A Randomized Controlled Clinical Trial
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Le résumé fourni par la source
Objectives: Hypericum perforatum (H. perforatum) has natural anti-inflammatory properties when used as a dressing on ulcers and burn wounds. The aim of this study was to investigate the effect of topical application of hydroethanolic gel of H. perforatum on soft tissue healing in tooth extraction sockets. Materials and Methods: This split-mouth randomized controlled clinical trial was performed on 30 patients aged 18-30 years who required simultaneous extraction of maxillary premolars bilaterally for orthodontic reasons. After tooth extraction, 2mL of 3% H. perforatum gel was injected into the extraction socket in the intervention side. Pain was measured based on a Numeric Rating Scale (NRS). Socket healing was assessed using the standardized Landry, Turnbull, and Howley index. Repeated measures ANOVA and generalized estimating equations (GEE) were employed to compare different indices between the two groups (alpha=0.05). Results: The mean age of the participants was 23.53 years. Of all, 25 were females and 5 were males. The intervention side had a significantly lower pain than the control side (P<0.05). The wound size decreased at 3 and 7 days, and it was smaller in the intervention side than the control side (P<0.05). The healing index score was significantly higher in the intervention side than the control side (P<0.001). Conclusion: The results showed that 3% H. perforatum hydroethanolic gel was effective for promoting soft tissue healing in tooth extraction sockets, decreasing pain, and improving the wound healing index.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Effect of Hypericum perforatum on Early Wound Healing after Tooth Extraction: A Randomized Controlled Clinical Trial
- Date Crossref
- 19/04/2026
- Éditeur
- Knowledge E DMCC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Kurdistan University of Medical Sciences Student Research Committee pays non établi dans la noticeUniversité ou école supérieure
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Mazandaran University of Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
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School of Health Student Research Committee pays non établi dans la noticeUniversité ou école supérieure
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School of Dentistry Department of Orthodontics pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Dentistry Department of Pediatric Dentistry pays non établi dans la noticeUniversité ou école supérieure
Student Research Committee — Kurdistan University of Medical Sciences, Mazandaran University of Medical Sciences et Student Research Committee — School of Health, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.