IL-36 Receptor Antagonist Spesolimab for Generalized Pustular Psoriasis Combined with Palmoplantar Pustulosis: A Case Report

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Hongyan Tan,1,* Yu Zhang,2,* Bin Zhang,3 Juan Wang,3 Zhong Zhang,3 Jizhen Zhong,3 Xiao Qiu,3 Xiangyu Hu,3 Ling Tang4 1Department of Dermatology, Shantou Hospital of Traditional Chinese Medicine, Shantou, 515031, People’s Republic of China; 2Department of Dermatology, Chongqing Liangjiang New Area Hospital of Traditional Chinese Medicine, Chongqing, 401122, People’s Republic of China; 3Department of Dermatology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400011, People’s Republic of China; 4Department of Administrative Management, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400011, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiangyu Hu, Department of Dermatology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400011, People’s Republic of China, Email 369930758@qq.com Ling Tang, Department of Administrative Management, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400011, People’s Republic of China, Email woshitangling1@163.comObjective: We have entered the era of using biologics and small-molecule targeted drugs to treat diseases. Although there have been many reports on the use of the anti-interleukin-36 (IL-36) receptor antagonist spesolimab for the treatment of generalized pustular psoriasis (GPP) recently, the clinical application of spesolimab for the treatment of GPP combined with PPP (palmoplantar pustulosis) is rarely reported, and there is a lack of evidence on the safety and efficacy of the spesolimab.The clinical application of spesolimab for GPP combined with palmoplantar pustulosis (PPP) is rarely reported, and evidence on its safety and efficacy remains insufficient. We aimed to explore the use of spesolimab for GPP combined with PPP and observed significant efficacy without obvious side effects, thereby providing new ideas for the clinical treatment of GPP combined with PPP.Methods: We reported a case of GPP combined with PPP treated with spesolimab, which achieved significant therapeutic effects without significant side effects.Results: This case report shows that spesolimab has good clinical efficacy in treating GPP combined with PPP. In this case, the presence of PPP may have delayed the rapid and complete clearance of the skin lesions.Conclusion: Spesolimab provides a new treatment option for patients with GPP combined with PPP.Keywords: generalized pustular psoriasis, IL-36, spesolimab, palmoplantar pustulosis, secukinumab

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