Impacts of personal or family COVID-19 infection on health-related quality of life among patients with opioid use disorder

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Objective: To assess the impacts of personal or family COVID-19 infection on health-related quality of life (HRQOL) among patients with opioid use disorder (OUD). Methods: From July 2021-July 2022, adults recruited from an OUD treatment clinic self-reported personal or family experiences of COVID-19 infection including exposures, quarantine, symptoms, positive tests, treatment, and severe illness. (one point for each positive response). HRQOL outcomes included (1) single-item general health (range: poor to excellent), and (2) HRQOL dimensions (problems with mobility, self-care, usual activities, pain/discomfort, anxiety/depression). Logistic regression quantified associations between COVID-19 impact scores and odds of (1) poorer general health and (2) each HRQOL dimension. Results: Among 149 participants, the average age was 49, 62.2% were white/non-Hispanic, 57% were male and median COVID-19 impact score was 4(IQR: 2-8). Many experienced problems with mobility (41.9%), usual activities (41.9%), and anxiety/depression (73.0%). Higher COVID-19 scores were associated with increased odds of problems with mobility, usual activities, and anxiety/depression (aOR=1.10, 95%CI:1.02-1.17; aOR=1.07 95%CI:1.00-1.14; aOR=1.21, 95%CI:1.09-1.34, respectively). Conclusions: Increased COVID-19 infection impacts were associated with specific HRQOL problems with mobility, usual activities and anxiety/depression. Resources are needed to protect HRQOL for this at-risk population during times of stress and healthcare disruption.

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