Plasma metabolomics analysis in murine prerenal azotemia reveals changes in energy substrates, amino acid metabolism, and uremic toxins

Résumé fourni par la source

We completed the first untargeted plasma metabolomics analysis in a murine model of prerenal azotemia (PRA) and demonstrate that PRA has systemic consequences with numerous significantly altered metabolites and pathways. By comparing the metabolite signature to that of acute tubular injury (ATI), novel insights into the potential adverse consequences of PRA and potential methods to distinguish PRA from ATI were identified.

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