Accès ouvert déclaré
2026
article
Oxygen saturation and mortality for acute pulmonary embolism: multinational retrospective cohort study
David Jiménez, Roger D. Yusen, Juan Manuel Velasco, Raquel Morillo, Alfonso Muriel, Luis Jara‐Palomares, Laurent Bertoletti, Luis Manuel Hernández-Blasco, Aída Gil‐Díaz, Farès Moustafa, Ángeles Fidalgo, Parham Sadeghipour, Khanh Quoc Pham, Behnood Bikdeli, Manuel Monréal, Paolo Prandoni, Benjamin Brenner, Dominique Farge, Raquel Barba, Peter Verhamme, Hugo Hyung Bok Yoo, Radován Malý, Sebastian Schellong, Inna Tzoran, Pierpaolo Di Micco, Abílio Reis, Marijan Bosevski, Lucia Mazzolai, Joseph Anthony Caprini, My Hanh Bui, Araceli Abad Fernández, María Dolores Adarraga, Jesús Aibar, Alicia Alda, Joaquín Alfonso, Cristina Amado, M. Angelina-García, Juan I. Arcelus, Aitor Ballaz, Cristina Barbagelata, Manuel Barrón, B. Barrón‐Andrés, Fahd Beddar-Chaib, Erika Ivette Bencosme de Méndez, Ángeles Blanco-Molina, S Calvo-Pascual, Núria Chamorro, Leyre Chasco, Gisela Claver, Patricia Crecente, Juan Criado, C. de Ancos-Aracil, C. De Juana-Izquierdo, Jorge Del Toro, Nieves Delgado‐Casado, Pablo Demelo-Rodríguez, María del Carmen Díaz-Pedroche, José Antonio Díaz‐Peromingo, Álvaro Dubois-Silva, Diego Durán, José Carlos Escribano, Ana Isabel Farfán-Sedado, Lara Almudena Fernández-Bermejo, Carmen Fernández-Martínez de Septién, José Luis Fernández‐Reyes, María Fuentes-Spínola, Cristina Gabara, Alberto García-Ortega, Olga Gavín-Sebastián, Covadonga Gómez-Cuervo, Santiago Enrique Gómez-Mañas, Juan Gorostidi-Pérez, Leticia Guirado, Javier Gutiérrez-Guisado, Jacinto Hernández-Borge, M.D. Joya, Antonio Lalueza, Ane Larrauri, Jaime Laureiro, Ramón Lecumberri, Pilar Llamas, Helena López-Brull, Luciano López-Jiménez, Patricia López-Miguel, J J López-Núñez, Marina López-Rubio, Antonio López‐Ruiz, Juan Bosco López-Sáez, Elena Madroñal‐Cerezo, Ana Maestre, Pablo Javier Marchena, M.V. Marcos, Mar Martín-del Pozo, María Isabel Mercado, Jorge Moisés, Laura Monzón-Escribano, Sara Moreno-Casas, María Sierra Navas, José Antonio Nieto, Manuel Jesús Núñez-Fernández, M. Olid, José Luis Orcastegui, Lucía Ordieres-Ortega, María Ortiz, Jeisson Osorio, S. Otálora, Remedios Otero, Javier Pagan, Pedro Parra, José María Pedrajas, C Pérez-Ductor, Montserrat Pérez‐Pinar, María Luisa Peris, M. L. Pesce, José Antonio Porras, Luís Miguel Prieto-Gañán, Gabriel Puche, Agustina Rivas, F. Rivera-Cívico, Ana Rodriguez-Cobo, Pedro Ruiz-Artacho, N. Ruiz‐Giménez, Paloma Ruiz-Torregrosa, Vanesa Sendín, Germán Sierra-Palomares, Patricia Sigüenza, Anna Solé, Susana Suárez‐Fernández, Raquél Tascón-Rodríguez, Raimundo Tirado, María Roca Toda, Carles Tolosa, Javier Trujillo-Santos, Lorena Tudela, Fernando Uresandi, Reina Valle, José Felipe Varona, Elena Vega-Romero, David Vicente-Navarro, Gemma Vidal, Paula Villares, Jin Seok You, Cihan Ay, Stephan Nopp, Ingrid Pabinger, Margot Erard, Quentin Van Thillo, Sebastián Enrique Carbonell, Ana Cristina Montenegro, Jairo Roa, Petr Grenar, Jana Hirmerova, Sandrine Accassat, Imane Boulmerka, A. Bura-Rivière, Judith Catella, Romain Chopard, Francis Couturaud, Benjamin Crichi, Arzu Demir, Olivier Espitia, Raphael Le Mao, Isabelle Mahé, Pierre Morange, L. Plaisance, Géraldine Poénou, I. Quéré, Gabrielle Sarlon-Bartoli, Pierre Suchon, E. Versini, Yaser Jenab, Alireza Khodayari, Somayeh Yadangi, Najib Dally, Giovanni Barillari, Manuela Basaglia, Franca Bilora, Danielle Bissacco, Cristiano Bortoluzzi, Matteo Bortoluzzi, B. Brandolin, Renato Casana, Maurizio Ciammaichella, Anna Guida, Daniela Lambertenghi-Deliliers, Chiara Marcon, Daniela Mastroiacovo, Umberto Mazzarelli, Valentina Pizzuti, Alessandra Poz, Paolo Scarinzi, Carmine Siniscalchi, Adriana Visonà, Ngoc Vo Hong, Beniamino Zalunardo, Haralds Cesnieks, Andris Skride, Matiss Zicans, Carlos Flores-Ramírez, Miguel Ángel Mendoza Romo-Ramirez, Daniel Tarín-Recéndez, Samuel Fonseca, Carla Fontes, Jose Meireles, Elif Vrajnko, Marija Zdraveska, Stefano Barco, Dominick Joseph Angiolillo, Luis Ortega-Paz, Alfonso Tafur, Son Truong Nguyen, Giang Binh Tran
1Citations signalées — pas une note de qualité
19Institutions déclarées
5Pays d’affiliation déclarés
Résumé fourni par la source
Background Among patients with acute pulmonary embolism ( PE ), we aimed to evaluate for an association between oxygen saturation ( SatO 2 ) and 30-day post-PE mortality. Methods Between January, 2001 and April, 2025, we conducted a retrospective cohort study of 38,739 non-hypotensive patients with acute PE enrolled from 18 countries in the Registro Informatizado de la Enfermedad Tromboembólica ( RIETE ) registry. Outcomes included 30-day all-cause and PE-specific mortality. We used hierarchical logistic regression to assess for an association between baseline SatO 2 and outcomes. We aimed to identify optimal SatO 2 cut-off points that maximized sensitivity and specificity in relation to mortality from receiver operating characteristic ( ROC ) curves. RIETE is registered with ClinicalTrials.gov, NCT02832245. Findings Baseline SatO 2 was significantly associated with mortality, where lower SatO 2 had worse outcomes. Using a reference SatO 2 of >96%, patients in the lower SatO 2 strata had higher rates of all-cause death (odds ratio [ OR ] 0.96 for SatO 2 94–96%; 1.23 for SatO 2 90–93%; and 1.81 for SatO 2 <90%) and PE-related mortality (OR 1.68 for SatO 2 94–96%; 2.04 for SatO 2 90–93%; and 3.95 for SatO 2 <90%). The optimal cut-off point to identify patients at low-risk for short-term mortality was SatO 2 of 96% (sensitivity of 86.1% and negative predictive value of 96.7%); while SatO 2 of 90% (specificity of 77.2% and positive predictive value of 7.9%) identified patients at increased risk for mortality. Interpretation Among non-hypotensive patients diagnosed with PE, we found an inverse association between baseline SatO 2 and odds of all-cause and PE-associated mortality over the subsequent 30 days. A SatO 2 cutoff value of 96% for the highest SatO 2 group while breathing room air might help better identify patients with acute PE at low-risk for mortality. Future studies should assess the contribution of SatO2 in addition to established prognosticators to predicting the risk of death. Funding ROVI.
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Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Oxygen saturation and mortality for acute pulmonary embolism: multinational retrospective cohort study
- Date Crossref
- 01/04/2026
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Sujets associés
Venous Thromboembolism Diagnosis and ManagementSepsis Diagnosis and TreatmentRespiratory Support and Mechanisms