A Follow-up Study of Peripheral Neurological and Biochemical Involvement in Gestational and Overt Diabetes Mellitus
Rattachement africain : in. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background ‘Hyperglycaemia in pregnancy’ (HIP) is one of the most common antenatal complications, affecting about one in six pregnancies globally. HIP is sub-classified into two categories, namely ‘gestational diabetes mellitus’ (GDM) and ‘overt diabetes mellitus’ (ODM). Pregnancy is characterised by the accumulation of adipose tissue and a growing placenta, acting as endocrine organs, thus intensifying the hyperglycaemic environment and building up oxidative stress by dysregulation of metabolic pathways, instigating peripheral neuropathy. Purpose Due to paucity in existing literature on neurological influences of GDM and ODM, this follow-up study was planned to detect subclinical peripheral neuropathy by nerve conduction studies (NCS) and its correlation with biochemical parameters among them. Methods Thirty-nine pregnant women were divided into three groups: control, GDM and ODM. The NCS (sural and ulnar nerves) and biochemical parameters, that is, fasting plasma glucose (FPG), glycated haemoglobin (HbA1c), serum fasting insulin, homeostatic model assessment of insulin resistance (HOMA-IR), serum chromium, serum N-carboxy-methyl lysine, total cholesterol, low-density lipoprotein, triglycerides and high-density lipoprotein, were recorded during different stages of gestation, that is, 24–28 weeks (first visit), 32–38 weeks (second visit) and 6–12 weeks after parturition (third visit). Results Nerve conduction studies reveal significant alterations in diabetic pregnant groups compared to control pregnant women, particularly in sensory latencies and amplitudes of the sural and ulnar nerves. Significant hyperglycaemia (FPG, HbA1c), hyperinsulinaemia, and elevated HOMA-IR in GDM and ODM groups confirm insulin resistance and poor glycaemic control during pregnancy and postpartum. Chromium levels were markedly lower in diabetics ( p = .001). Conclusion This study necessitates ongoing metabolic and neurological monitoring in GDM and ODM after childbirth. Early screening and focused interventions, including micronutrient supplementation and lifestyle modifications, may help avert progression to overt neuropathy and mitigate long-term complications.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- A Follow-up Study of Peripheral Neurological and Biochemical Involvement in Gestational and Overt Diabetes Mellitus
- Date Crossref
- 14/04/2026
- Éditeur
- SAGE Publications
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
All India Institute of Medical Sciences Raipur pays non établi dans la noticeUniversité ou école supérieure
-
All India Institute of Medical Sciences Bhopal pays non établi dans la noticeUniversité ou école supérieure
-
All India Institute of Medical Sciences Rishikesh pays non établi dans la noticeOrganisme public
-
Seema Dental College and Hospital pays non établi dans la noticeUniversité ou école supérieure
-
Department of Physiology pays non établi dans la noticeInstitution
-
Department of Biochemistry pays non établi dans la noticeInstitution
-
Department of Obstetrics & pays non établi dans la noticeInstitution
-
Department of Pharmacology pays non établi dans la noticeInstitution
All India Institute of Medical Sciences Raipur, All India Institute of Medical Sciences Bhopal et All India Institute of Medical Sciences Rishikesh, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.