A sodium phytate–ethyl cellulose coating with sustained oleoyl serine release enables spatiotemporal osteoimmune regulation of magnesium implants

Le résumé fourni par la source

Biodegradable magnesium Mg implants hold immense potential in orthopedics , yet their rapid degradation , insufficient osseointegration , and immune imbalance remain major barriers to clinical translation . This study developed a sodium phytate SP passivation layer and an ethyl cellulose EC barrier loaded with oleoylserine OS multifunctional coating on Mg implant surfaces . This SP − EC − OS coating achieves spatiotemporal synergistic regulation through a triple mechanism of “ chemical passivation , barrier isolation , signal − controlled release . ” The SP layer enhances interfacial bonding strength and corrosion resistance , the EC layer provides a platform for controlled degradation and sustained release , while the continuous release of OS synergistically modulates cellular behavior with Mg 2 + . In vitro results demonstrated that the Mg − SP − EC − OS significantly enhancing corrosion resistance while its programmable release synchronizes with the bone regeneration cascade . More importantly , the synergistic effect of OS and Mg 2 + promotes osteoblast differentiation and mineralization , inhibits osteoclast activation , and induces macrophage polarization toward the M2 phenotype , achieving immune regulation − driven bone regeneration . In vivo validation of the femoral defect model in rats has shown that Mg − SP − EC − OS implants induce macrophage polarization toward the M2 phenotype through immune regulation , significantly promote new bone formation , reduce bone − implant interface cavities , and maintain excellent systemic biosafety . This multifunctional coating combines corrosion resistance , immunomodulation , and spatiotemporal osteogenic effects , achieving spatiotemporally controlled degradation aligned with the bone healing process . It provides a viable strategy for developing a new generation of degradable magnesium − based orthopedic implants .

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