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2026
article
Colon cancer with a peritumoural abscess: Real-world evidence on prognostic and therapeutic implications of a disregarded entity
Eva Rademaker, Jannes M. van der Woude, R. van den Berg, Richard M. Brohet, Petur Snaebjornsson, Ignace H J T de Hingh, Niels F M Kok, Esther C.J. Consten, Henderik L. van Westreenen, Pieter J. Tanis, D.C. Van der Aa, S.M. Van Aalten, I. Aanen, F.J. Amelung, P. Van Amstel, E. Ancion, JJ Atema, T.S. Aukema, V. Baart, E.Z. Barsom, V.P. Bastiaenen, T. Bazuin, M.A.J. Becker, HJ Belgers, V.M. Belvroy, R.H.A. Berndsen, B. Biersteker, J.D.W. Van der Bilt, J.G. (Johanne) Bloemen, S. Bluiminck, FC den Boer, EG Boerma, MC Boonstra, WAA Borstlap, L.A. Brugts, J.W.A (Jacobus) Burger, T.A. Burghgraef, S.M.M. De Castro, M. Cleveringa, R.J.S. Coelen, J.W.T. Dekker, A. Demirkiran, E. Dijkema, S. Dijkink, S.A. Dingemans, L. Van Dullemen, EB Van Duyn, A.J. Eleveld, H.A. Galema, E.G.M. Van Geffen, R.T.J. Geitenbeek, A.A.W. Van Geloven, AHC Gielen, C.A. Gispen, M.J.P.M. Govaert, W.M.U. Helma van Grevenstein, V.P. Groot, B.A. Grotenhuis, A.A.J. Grüter, S.F. Hardon, A.G. Den Hartog, K. Havenga, J.A.G. Van der Heijden, F. Heilijgers, T.B.M. Van den Heuvel, RS Hijmans, J. Van Hilst, I. Hochstenbach, C. Hoff, J.C. Hol, S. Janki, A.C.H.M. Jongen, I. Kappers, S. Karhof, B.A.J. Kertzman, M.M. Kieboom, N. Koemans, Dr J.L.M. Konsten, WH Kopp, O. Kranenburg, P. Krielen, A. Kumas, M. Kusters, D.P.V. Lambrichts, B. Lamme, G.L. Van Leeuwen, J. W. A. Leijtens, E.W. Lockhorst, H. Lutfi, S. Malm, H. T. J. Mantel, G.A. Martini, P. Meijer, J. Melenhorst, D.M. Mens, M.J.H. Metman, L.R. Moolenaar, L.C.F. De Nes, JA Nieuwstraten, J. Nonner, S.E. Van Oostendorp, S.J. Oosterling, K.C.M.J. Peeters, CMW Pesch, C.M.L. Peters, M.W.H. Philipsen, W.Y. Van der Plas, M.M. Poelman, F. Polat, A.E. Posma-Bouman, B.B. Pultrum, J.M. van Rees, W.P. Reinders, P.R. de Reuver, M.C. Richir, T.W.H. Rijnhout, M.M. Romeijn, D. Roorda, CC van Rossem, J. Rothbarth, M. Ruig, H.G. Sahin, I. Said, R.A. Schasfoort, J. Scholten, J.M.j. Schreinemakers, P.M.E. Schuivens, D. Schweitzer, C. Sietses, M. Sietzema, G.D. Slooter, N. Smakman, B.P. Smalbroek, A.B. Smits, E. J. Spillenaar Bilgen, E. J. A. Steller, T.F. Stoop, M. Straver, S.K. Stuart, A. Suntharan, A K Talsma, K. Trumpi, J.B. (Jurriaan) Tuynman, J. Veenhuizen, A.W.H. Van de Ven, E.G.G. Verdaasdonk, P.M. Verheijen, A. Villerius-Meijer, M. Vissers, E.L.K. Voogt, R. P. H. De Vries, S.T. Van Vugt, D.D. De Waard, T.R. Wagner, A.K. Warps, R.H.A. Welling, M. Westerterp, JK Wiggers, AR Wijsmuller, C.D.M. Witjes, B. Zamaray, N. Van Zenden, DDE Zimmerman, S.J.M. Zomer, E.S. Zwanenburg, E.S. Zwar, S.L.M. Zwetsloot, A.G.J. Aalbers
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Résumé fourni par la source
INTRODUCTION: Colon cancer with a peritumoural abscess (CCPA) is an uncommon disease entity. This study aimed to analyse its prognostic implications and to evaluate strategies to treat CCPA using real-world data. METHODS: This was a multicentre cross-sectional cohort study of patients who underwent resection of stage I-IV colon cancer in 50 Dutch hospitals in 2014-2015. Patients with CCPA were propensity score matched to controls without CCPA (1:4). Additional outcome analyses were performed after stratifying treatment of CCPA into acute/urgent resection, bridge-to-surgery (BTS), and planned resection. RESULTS: CCPA was diagnosed in 244/9040 patients (2.7%). Of these patients, 243 were matched to 967 control patients. Five-year locoregional recurrence rate was higher in CCPA (30.8% vs 11.9%, HR 1.64, 95% CI 1.06-2.54) with non-significantly lower 5-year overall survival (52.7% vs 60.6%, p = 0.34). Among patients with CCPA, 98 (40.2%) underwent acute/urgent resection, 48 (19.7%) BTS approach, and 98 (40.2%) planned resection. Patients managed with BTS had the highest proportions of 90-day complications (75%, p = 0.05), reinterventions (60%, p = 0.003), and permanent stoma (44%, p = 0.02). Five-year LRR rates were 32% for acute/urgent resection, 43% for BTS, and 24% for planned resection (p = 0.12). Locoregional recurrences were predominantly peritoneal metastases in the acute/urgent resection group and anastomotic recurrences in the BTS group. Corresponding 5-year overall survival rates were 45%, 51%, and 60%, respectively (p = 0.05). DISCUSSION: The presence of a peritumoural abscess was associated with a higher risk of locoregional recurrence, possibly influenced by the therapeutic strategy applied. Future studies should focus on optimizing treatment approach to reduce the high burden of CCPA.
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Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Colon cancer with a peritumoural abscess: Real-world evidence on prognostic and therapeutic implications of a disregarded entity
- Date Crossref
- 01/06/2026
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
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