Brain-heart interaction: direct and indirect circuits in health and diseases
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Le résumé fourni par la source
BACKGROUND: Epidemiological data indicate a significant global increase in both comorbidity and mutually induced rates between cardiovascular and neurological diseases. Among these, cardiovascular and cerebrovascular diseases share eleven co-localized loci. The critical role of the brain-heart axis in these processes has been increasingly recognized. This axis mediates dynamic bidirectional crosstalk via neuroendocrine, neuroimmune and related pathways, with key mediators including the hypothalamic-pituitary-adrenal (HPA) axis, gut-derived metabolites, extracellular vesicles (EVs), and autonomic nervous system (ANS). Conventional siloed care across cardiology and neurology specialties, alongside single-organ targeted therapies, fails to effectively disrupt the pathological vicious cycle of brain-heart interactions. Targeting key mediators of the brain-heart axis holds significant clinical potential for the treatment of neurological or cardiovascular diseases. AIM OF REVIEW: This review systematically summarizes the key advances in brain-heart crosstalk over the past decade, delineates the direct neural pathways and indirect regulatory mechanisms between the two organs. Against this backdrop, we outline the clinical potential of nervous system-targeted strategies for cardiac disease and related neurological complications, alongside the broad promise of cardiac function optimization to modulate immune and endocrine pathways for cardio-cerebral comorbidity management. KEY SCIENTIFIC CONCEPTS OF REVIEW: We discuss the mediators underlying brain-heart crosstalk, and delineate the distinct functional roles of the brain-heart axis across diverse cardiovascular diseases and psychiatric disorders, offering new conceptual frameworks for treating cardiocerebral comorbidities.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Brain-heart interaction: direct and indirect circuits in health and diseases
- Date Crossref
- 01/04/2026
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Nanjing University of Chinese Medicine pays non établi dans la noticeUniversité ou école supérieure
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Tianjin University of Traditional Chinese Medicine pays non établi dans la noticeUniversité ou école supérieure
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First Teaching Hospital of Tianjin University of Traditional Chinese Medicine pays non établi dans la noticeÉtablissement de santé
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School of Integrative Medicine pays non établi dans la noticeUniversité ou école supérieure
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Affiliated Hospital of Nankai University Department of Traditional Chinese Medicine pays non établi dans la noticeUniversité ou école supérieure
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The First School of Clinical Medicine pays non établi dans la noticeUniversité ou école supérieure
Nanjing University of Chinese Medicine, Tianjin University of Traditional Chinese Medicine et First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.