Urinary non-persistent environmental chemicals in pregnancy: Associations with subclinical renal injury and exposure determinants
Rattachement africain : tw. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
• Phenols (BPA, NP) were strongly associated with early renal injury markers. • Parabens showed both individual and joint effects on NAG and ACR. • Phthalate mixture exposure increased ACR despite null single-metabolite results. • Personal care products and indoor environments drove major exposure patterns. • Exposure disparities were influenced by sociodemographic and lifestyle factors. Exposure to xenoestrogens—including phthalates, parabens, and phenols—as well as melamine is widespread; however, evidence regarding their combined effects on early renal injury during pregnancy remains limited . We examined associations between urinary concentrations of nine phthalate metabolites, four parabens, two phenols, and melamine and renal injury biomarkers—N-acetyl-β-D-glucosaminidase (NAG) and albumin-to-creatinine ratio (ACR)—among 1,433 pregnant women in Taiwan. Exposure determinants were assessed using structured questionnaires. Individual and cumulative exposure effects were evaluated by using compound-based summed exposure indices and principal component analysis (PCA) to characterize mixture patterns. In single-chemical models, methylparaben, butylparaben, nonylphenol, and bisphenol A were significantly associated with log-transformed NAG and ACR, while melamine was associated with NAG. Compound-based analyses revealed that phenols exhibited the strongest cumulative associations with both renal biomarkers, followed by parabens for NAG. Although individual phthalate metabolites were not significantly associated with renal markers, cumulative phthalate exposure was positively associated with ACR after covariate-adjusted creatinine standardization. PCA identified exposure patterns linked to personal care product use (parabens) and indoor environmental factors (phthalates), with regional variability observed. Phenols showed consistent associations despite uncertainty regarding dominant exposure sources. The stronger effects identified through compound-based and PCA-derived mixture approaches underscore the importance of evaluating hazardous environmental contaminants as complex exposure profiles rather than as single chemicals. Given the heightened physiological susceptibility during pregnancy, these findings support mixture-oriented risk assessment and targeted exposure mitigation strategies to protect maternal renal health.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Urinary non-persistent environmental chemicals in pregnancy: Associations with subclinical renal injury and exposure determinants
- Date Crossref
- 01/05/2026
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Kaohsiung Medical University Research Center for Precision Environmental Medicine pays non établi dans la noticeUniversité ou école supérieure
-
National Health Research Institutes pays non établi dans la noticeOrganisation à but non lucratif
-
Research Center for Environmental Changes pays non établi dans la noticeStructure de recherche
-
Tzu Chi University Department of Public Health pays non établi dans la noticeUniversité ou école supérieure
-
National Yang Ming Chiao Tung University pays non établi dans la noticeUniversité ou école supérieure
-
Kaohsiung Medical University Chung-Ho Memorial Hospital pays non établi dans la noticeÉtablissement de santé
-
Kaohsiung Municipal Hsiao-Kang Hospital pays non établi dans la noticeÉtablissement de santé
-
Institute of Population Health Sciences pays non établi dans la noticeStructure de recherche
-
National Environmental Health Research Center pays non établi dans la noticeStructure de recherche
-
College of Medicine Institute of Environmental and Occupational Health Sciences pays non établi dans la noticeUniversité ou école supérieure
-
Department of Laboratory Medicine pays non établi dans la noticeStructure de recherche
Research Center for Precision Environmental Medicine — Kaohsiung Medical University, National Health Research Institutes et Research Center for Environmental Changes, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.