How long should washout be to reliably measure hepatic de novo lipogenesis using deuterated water? Exploratory analysis from a randomized crossover trial

Résumé fourni par la source

Repeated deuterated water dosing in humans does not systematically bias measures of fasting hepatic DNL when using a washout duration of ∼4 wk. Fasting fractional hepatic DNL can be reliably assessed using deuterated water over sequential visits with as little as 3 wk washout between measures. At the group level, the within-participant variability in fasting hepatic DNL was relatively small and permits efficient detection of minimal clinically important differences in hepatic DNL with crossover studies.

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