Scoping review on the relationship between microRNAs (miRNAs) and short sleep disorder or insomnia with short sleep duration
Rattachement africain : es, pt. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background: MicroRNA (miRNA) stands for a class of small, non-coding RNA molecules, typically forming 20 to 25 nucleotides in length, which play a pivotal role in the regulation of gene expression in eukaryotic cells. These molecules are integral to the post-transcriptional regulation of target messenger RNA (mRNA), which they achieve primarily through binding to complementary sequences within the 3' untranslated region (UTR) of the mRNA. miRNAs exert their regulatory effects by binding to their target mRNA, leading to two primary outcomes: mRNA degradation or inhibition of translation. This functionality positions miRNAs as crucial modulators of a variety of biological processes, including cell growth, differentiation, apoptosis, and responses to environmental stress. Furthermore, dysregulation of miRNA expression is associated with pathological conditions, including cancer, cardiovascular disease, and neurological disorders. They are associated with sleep regulation and are helpful in diagnosing diseases, including sleep disturbances. This scoping review aims to summarize existing literature in patients aged 18 to 65 with a main diagnosis of Short Sleep Disorder (SSD), and Insomnia with Short Sleep Duration (ISOSS) and its relationship with miRNAs. The objective of this study is to search for existing evidence on the composition (presence, diversity, and relative abundance) of miRNAs in individuals with and without sleep disturbances, and to know whether the cardiometabolic comorbidities associated with these pathologies imply miRNA alterations. Methods: This scoping review was performed according to the PRISMA-ScR checklist and the systematic literature search was conducted using Medline, Web of Science, and CINAHL, until June 2025. Results: Seven cross-sectional studies form the basis of this ScR. The miRNAs of particular interest include miR-182-5p, miR-4433b-3p, which are implicated in inflammatory pathways, and appear to be downregulated in conditions associated with sleep deprivation, thereby contributing to an exacerbation of pro-inflammatory responses that can lead to cardiovascular dysfunction. Also, miR-619-5p, linked to stress responses and cognitive and emotional health, miR-33a, miR-181d, implicated in lipid metabolism and neuroinflammation, miR-132-3p linked to increased risk of depression and cognitive decline and miR-125a, miR-126, and miR-146a, critical regulators of diverse biological processes, particularly in the context of inflammation and cardiovascular health. Conclusions: The existing literature sets up a foundational understanding of the relationship between miRNAs, insomnia (IS), SSD and ISOSS. Although the current evidence base is limited, dysregulation of specific miRNAs may play a role in the pathophysiology of IS, SSD and ISOSS; however, larger and methodologically standardized studies are required.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Scoping review on the relationship between microRNAs (miRNAs) and short sleep disorder or insomnia with short sleep duration
- Date Crossref
- 01/12/2026
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Universidad Europea de Madrid Orofacial Pain pays non établi dans la noticeUniversité ou école supérieure
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University of Lisbon Sleep Unit pays non établi dans la noticeUniversité ou école supérieure
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Universidade Europeia pays non établi dans la noticeUniversité ou école supérieure
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Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud pays non établi dans la noticeOrganisation à but non lucratif
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Universidad Europea de Andalucía pays non établi dans la noticeUniversité ou école supérieure
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Universidad de Málaga pays non établi dans la noticeUniversité ou école supérieure
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Universidad Complutense de Madrid pays non établi dans la noticeUniversité ou école supérieure
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Research Institute Hospital 12 de Octubre pays non établi dans la noticeÉtablissement de santé
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Hospital Universitario La Paz pays non établi dans la noticeÉtablissement de santé
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Faculty of Biomedical and Health Sciences Universidad Europea de Madrid pays non établi dans la noticeUniversité ou école supérieure
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European Sleep Centre pays non établi dans la noticeInstitution
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Faculty of Biomedical Sciences and Sports Department of Biomedicine and Dentistry pays non établi dans la noticeUniversité ou école supérieure
Orofacial Pain — Universidad Europea de Madrid, Sleep Unit — University of Lisbon et Universidade Europeia, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.