Editorial: Neuroglycobiology

Le résumé fourni par la source

Neuroglycobiology sits at the intersection of neuroscience and glycobiology, focusing on how glycans and glycoconjugates shape brain development, function, and disease. Glycosylation influences virtually every level of nervous system biology, from cell–cell communication and extracellular matrix (ECM) organization to synaptic plasticity, myelination, and neuroinflammation (Figure 1). Despite this centrality, brain glycans (and indeed glycans in general) have historically been underexplored, largely due to their structural complexity and the technical challenges associated with their analysis. Methodological advances and a growing recognition of the brain’s unique glycosylation landscape have stimulated research activity in the field in recent years. The present Research Topic brings together six articles that highlight the breadth of contemporary neuroglycobiology, spanning human disease, brain development, ECM biology, and protein-specific glycosylation. Collectively, these contributions illustrate how diverse classes of glycans—from glycosaminoglycans to N- and O-linked glycans—contribute to molecular signaling pathways in the healthy and diseased nervous system.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.