Factors Affecting Disaese Recurrence and Overall Survival in High-Grade Endometrial Cancer Patients

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Objective: The main objective of present study was to determine the factors affecting disease recurrence and overall survival in patients with high-grade endometrial cancer.Methods: The study retrospectively included women who underwent primary surgery between January 2017 and December 2021 and were diagnosed with serous, clear cell, carcinosarcoma, mixed type, grade 3 endometrioid or DE/undifferentiated endometrial cancer histology as documented in postoperative pathology reports.The data set was obtained from patient files and an electronic gynaecological oncology clinic database.Results: A total of 81 patients were included in the analysis.26 (32.1%) patients had recurrence.Pelvic lymph node positivity, para-aortic lymph node positivity, disease stage and adjuvant treatment were associated with disease recurrence.P values were 0.005, 0.009, 0.019, 0.002 and 0.009, respectively.Overall survival duration was 39 months.In multivariate analysis, only histotype (DE/undifferentiated, Hazard ratio (HR): 4.028 Confidence interval (CI): 1.208-13.434;P=0.023) and positive peritoneal cytology (HR: 3.719; CI:1.408-9.827;P=0.008) were significant independent prognostic factors for overall survival.Conclusion: Histotype and positive peritoneal cytology may be associated with a worse overall survival in high-grade endometrial cancers.

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