Frequency and short-term persistence of haematuria and/or proteinuria in neonates: a cohort study

Le résumé fourni par la source

Purpose Haematuria and proteinuria may point to kidney diseases, but may also be found incidentally. Among schoolchildren, many studies suggest their prevalence to around 1%. In neonates, the frequency and persistence of haematuria and/or proteinuria in the general population have so far not been investigated systematically. Methods In the course of the prospective KUNO-Kids Health Study, urine samples were collected and analysed by dipstick in asymptomatic neonates on days three to five after birth. Those with positive findings underwent a maximum of two follow-ups until 16 weeks of age and factors associated with haematuria and/or proteinuria were explored. Results Of 509 participants with a urine sample available, 27% (n = 139) exhibited positive results. Of these, 58% (n = 81) had isolated haematuria, 21% (n = 29) had isolated proteinuria, and 21% (n = 29) had both. Of all children with positive urine tests, 76% (n = 105) underwent a first follow-up (mean 7 weeks later), and only in 1.9% (n = 2) was a positive result found. In the second follow-up (mean 2 weeks later), no positive results were detected anymore. Positive urine test results were more common in females and after vaginal delivery (p < 0.001 and p = 0.037, respectively). Conclusion: The present study identified haematuria and/or proteinuria in a significant proportion of healthy newborns shortly after birth, but results returned to normal within weeks in all participants available for follow- up. Thus, isolated findings of haematuria and/or proteinuria in newborns should be interpreted with caution.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.