Study on development of the cerebellar cortex in rats exposed to X-irradiation in utero

Le résumé fourni par la source

Development of the cerebellar cortex in the rat prenatal exposed to X-irradiation was studied. Females were exposed to X-ray at a single dose of 2.0 Gy on embyonic day 21. Cerebellar samples from pups were obtained at different postnatal days. Sections from the samples were serially cut off in a sagittal plane, and then incubated with anti-calbindin-D28 K and anti-inositol 1, 4, 5-triphosphate receptor antibody. The settled Purkinje cells were lined up in the monolayer and their dendritic plexus was always oriented perpendicular to the long axis of the lobule in the control rat. However, such Purkinje cells in the posterior lobes of the irradiated rat formed multi-layers, and orientation of their dendritic plexus was disordered. X-irradiation at the end of rat pregnancy might prevent mainly the generation of the Purkinje cell that played important roles for neuronal pathways.

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