Antidyslipidemic Effects and Improvement in Lecithin–Cholesterol Acyltransferase (LCAT) Activity Following Dietary Supplementation with a Mixture of Olea europaea and Cynara scolymus Leaves in a Rat Model

Résumé fourni par la source

Background: Olea europaea (OeP) and Cynara scolymus (CsP) are commonly found in the Mediterranean region, including Algeria, and have traditionally been used to treat various ailments, including dyslipidemia. Aim: To explore the activity of lecithin-cholesterol acyltransferase (LCAT) in OeP and CsP leaves using a hypercholesterolemia diet-induced dyslipidemia model in rats. Materials and Methods: To develop the dyslipidemia animal model, 21 adult Wistar rats were chosen and fed a hypercholesterolemia diet (2% cholesterol and 1% cholic acid) for up to 15 days. Dyslipidemia was confirmed in the rats through biochemical tests. Subsequently, the rats were given a diet enriched with couscous and Oep and Csp leaves powder supplements (1%) for 15 days of consecutive treatment. Under sodium pentobarbital anesthesia, blood samples were collected and stored at -70°C for biochemical analysis. Results: The study revealed that the Oep and Csp leaves treated dyslipidemia rats significantly (p<0.01) decreased FSG, TC, FC, TG, phospholipids, LDL-c, ApoB-100, creatinine, urea, AST and ALT. By contrast, other biochemical parameters, including HDL-C, LCAT, and ApoA-I, were significantly (p<0.01) improved compared to the dyslipidemia control rats. Conclusion: Current investigation concludes that OeP and CsP leaves exhibit lipid-lowering and anti-dyslipidemia effects by enhancing LCAT activity in hypercholesterolemia-induced dyslipidemia model rats.

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