Betaine based organ preservation solution alleviates renal allograft I/R injury by protecting endothelial cells

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Abstract Static cold preservation remains a cornerstone of transplantation, and high-performance organ preservation solutions, sharing the same goal as regenerative biomaterials, are indispensable for facilitating the regeneration and functional recovery of organs following transplantation. In this study, we developed a betaine-based organ preservation solution (BOPs), combined with the optimization of osmotic pressure components and energy support components. In the endothelial cell inflammation model, BOPs exhibited robust antioxidative and anti-apoptotic effects. Across multiple stages of kidney transplantation, including static cold storage, early reperfusion and the post-in situ transplantation period, BOPs demonstrated organ preservation efficacy comparable to that of the University of Wisconsin (UW) solution. Owing to its favorable efficacy and cost-effectiveness, BOPs hold broad market prospects.

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