Characterization of the gut phageome and functional genes carried by phages in laying hens with fatty liver hemorrhagic syndrome
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Le résumé fourni par la source
BACKGROUND: The gut microbiota is closely associated with the development of fatty liver hemorrhagic syndrome (FLHS); however, the function of its viral component, particularly bacteriophages, remains poorly understood. This study compared clinical parameters and the cecal phageome between 30-week-old (W30) and 50-week-old (W50) laying hens to characterize gut phages in the context of this metabolic disorder. RESULTS: Clinical analysis revealed that the W50 group exhibited typical FLHS, accompanied by elevated serum liver function and lipid markers (P < 0.05). Functional prediction of the gut microbiota suggested a reduced lipid-metabolic capacity in W50 compared to the W30 group. A total of 20,274 phage genomes were identified from the two groups. These phages were primarily classified into 67 viral families, including Salasmaviridae, Herelleviridae, Suoliviridae, Peduoviridae, Crevaviridae, and Casjensviridae. The families Druskaviridae, Felixviridae, and Stanwilliamsviridae were uniquely detected in the W50 group. The phage community structure differed significantly between groups, with both phage diversity and richness markedly lower in W50 (P < 0.05). LEfSe analysis revealed that phage taxa such as Stegnyidae, Herpelidae, and Chasovidae were significantly enriched in the W50 group, whereas Crewdviridae, Salasmaviridae, and Castroviridae were predominantly enriched in the W30 group. Functional annotation showed that these phages encode numerous metabolism-related genes and carry antimicrobial resistance genes (ARGs) as well as virulence factor genes. Notably, the diversity of ARGs carried by W50 phages was significantly higher (P < 0.05), and ARG-rank analysis indicated a greater potential risk to human health. CONCLUSIONS: This study provides the first characterization of the gut phageome associated with FLHS in laying hens and confirms that gut phages constitute an important reservoir of ARGs. These findings offer a new perspective for understanding the pathogenesis of this disease and its associated public health risks. Video Abstract.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Characterization of the gut phageome and functional genes carried by phages in laying hens with fatty liver hemorrhagic syndrome
- Date Crossref
- 25/03/2026
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Hebei Agricultural University pays non établi dans la noticeUniversité ou école supérieure
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Hebei University pays non établi dans la noticeUniversité ou école supérieure
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Hebei Research Institute of Microbiology pays non établi dans la noticeStructure de recherche
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Baoding University pays non établi dans la noticeUniversité ou école supérieure
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Qingdao Institute of Animal Husbandry and Veterinary Medicine pays non établi dans la noticeStructure de recherche
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College of Traditional Chinese Veterinary Medicine pays non établi dans la noticeUniversité ou école supérieure
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Institute of Animal Husbandry and Veterinary Medicine of Hebei Province pays non établi dans la noticeStructure de recherche
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Baoding Vocational and Technical College pays non établi dans la noticeUniversité ou école supérieure
Hebei Agricultural University, Hebei University et Hebei Research Institute of Microbiology, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.