WCN26-2795 Genistein decreases albuminuria due to albumin endocytosis through caveolae into glomerular endothelial and epithelial cells by decreasing Src kinase activity

Résumé fourni par la source

Previously, we have been reported about the new etiology of albuminuria by caveolar mediated intracellular trafficking pathway of albumin in glomerular endothelial cells (GEnCs) and podocytes (Pod), and also researched novel therapeutic approach to reduce albuminuria by decreasing caveolae. Src kinase plays an important role of internalization of caveolae coated pits into cytoplasm as caveolae endocytosis. In this study, we analyzed whether Genistein (Gen), which was the non-steroidal phytoestrogen belonged to potent soy isoflavone, inhibited Src activity in GEnCs and pod, and resulted in decreasing albuminuria of puromycin aminonucleoside (PAN) induced nephrotic syndrome modeled mice.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.