Association between dyspnea and cognitive task performance in amyotrophic lateral sclerosis: An exploratory study
Rattachement africain : fr. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Dyspnea is a major sensory and emotional burden in patients with chronic respiratory insufficiency. While experimentally induced acute dyspnea has been shown to interfere with cognition in healthy participants, interferences between cognition and chronic clinical dyspnea have not been studied. We conducted an exploratory study to examine the association between dyspnea severity and cognitive performance in patients with amyotrophic lateral sclerosis (ALS) and chronic respiratory failure. Twenty patients were studied during unassisted breathing and during non-invasive ventilation (NIV). Dyspnea was assessed using the Multidimensional Dyspnea Profile, and cognitive performance was evaluated using the Paced Auditory Serial Addition Test (PASAT) and the Corsi block-tapping test. Respiratory-related cortical activity was assessed using electroencephalography. Linear mixed-effects models were used to examine associations between dyspnea descriptors and cognitive outcomes, adjusting for age, educational level, and disease severity. NIV markedly relieved dyspnea, anxiety, and respiratory-related cortical activity but was not associated with changes in cognitive performance. Dyspnea unpleasantness was independently associated with longer PASAT response time, whereas no associations were observed with PASAT accuracy measures or Corsi test outcomes. Neither ventilation condition nor respiratory-related cortical activity was associated with cognitive performance. These findings suggest that, in patients with ALS, dyspnea unpleasantness may be associated with slower PASAT response time without detectable relationships with other cognitive measures assessed in this study. Given the exploratory and focal nature of the study, further investigations are warranted to better characterize dyspnea–cognition interactions in this population. • Dyspnoea–cognition interactions have been described in experimental conditions. • Here, these interactions were explored in amyotrophic lateral sclerosis patients • Dyspnoea unpleasantness was selectively associated with slower PASAT response times • No association was found between dyspnoea and working memory or task accuracy • Non-invasive ventilation relieved dyspnoea but did not improve cognitive performance
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Association between dyspnea and cognitive task performance in amyotrophic lateral sclerosis: An exploratory study
- Date Crossref
- 01/05/2026
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Inserm pays non établi dans la noticeOrganisme public
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Université Fédérale de Toulouse Midi-Pyrénées pays non établi dans la noticeUniversité ou école supérieure
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Sorbonne Université Département de Pneumologie pays non établi dans la noticeUniversité ou école supérieure
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Sorbonne Paris Cité pays non établi dans la noticeInstitution
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Laboratoire de Statistique Théorique et Appliquée pays non établi dans la noticeStructure de recherche
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Assistance Publique – Hôpitaux de Paris pays non établi dans la noticeÉtablissement de santé
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Hôpitaux Universitaires Paris-Ouest pays non établi dans la noticeÉtablissement de santé
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Pitié-Salpêtrière Hospital pays non établi dans la noticeÉtablissement de santé
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Centre Hospitalier Universitaire de Toulouse pays non établi dans la noticeÉtablissement de santé
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Délégation Paris 7 pays non établi dans la noticeOrganisme public
Inserm, Université Fédérale de Toulouse Midi-Pyrénées et Département de Pneumologie — Sorbonne Université, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.